The association between genetic variants identified by GWAS and prostate cancer risk and mortality

• Project/Area Number: 24592378
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: The University of Tokyo
• Principal Investigator: MOTOFUMI Suzuki 東京大学, 医学部附属病院, 臨床登録医 (50401063)
• Co-Investigator(Kenkyū-buntansha): SANADA Masashi 京都大学, 医学(系)研究科(研究院), 助教 (20529044) ; HOMMA Yukio 東京大学, 医学部附属病院, 教授 (40165626) ; OGAWA Seishi 京都大学, 医学(系)研究科(研究院), 教授 (60292900) ; SATO Aiko 京都大学, 医学(系)研究科(研究院), 研究員 (70512573)
• Co-Investigator(Renkei-kenkyūsha): ARAI Tomio 東京都健康長寿医療センター, 研究員 (20232019)
• Research Collaborator: SUZUKI Yutaka 東京大学, 新領域創成科学研究科, 教授 (40323646)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 前立腺癌 / 遺伝子解析 / 一塩基多型

Outline of Final Research Achievements

We revealed that the TMPRSS2 Met160Val polymorphism was significantly associated with clinical prostate cancer risk in a native Japanese population. Comparing with Val/Val genotype, age-adjusted odds ratios (95% CIs) were 1.418 (1.030-1.956) for Val/Met and 1.906 (1.230-2.979) for Met/Met genotype, respectively. The polymorphism was not associated with the risk of latent prostate cancer.
We also conducted a replication study on 55 genetic polymorphisms that were associated with prostate cancer susceptibility found by genome-wide association studies. We found only 6 polymorphisms that located on chromosome 8 were significant risk factor of clinical prostate cancer in a native Japanese population. These 6 polymorphisms were not associated with the risk of latent prostate cancer, either.

Research Products

• [Journal Article] TMPRSS2 Met160Val polymorphism: significant association with sporadic prostate cancer, but not with latent prostate cancer in Japanese men. (2014)
  • Author(s): Maekawa S, Suzuki M, Arai T, Suzuki M, Kato M, Morikawa T, Kasuya Y, Kume H, Kitamura T, Homma Y.
  • Journal Title: International Journal of Uroogy Volume: 21 Issue: 12 Pages: 1234-1238
  • DOI: 10.1111/iju.12578
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] GWASで特定された一塩基多型と日本人における前立腺癌発症リスクおよび予後との関連について（第2報） (2014)
  • Author(s): 鈴木基文、前川滋克、鈴木穣、粕谷豊、新井冨生、鈴木誠、加藤司顯、藤村哲也、福原浩、中川徹、久米春喜、北村唯一、本間之夫
  • Organizer: 第102回 日本泌尿器科学会総会
  • Place of Presentation: 神戸市，神戸国際会議場
  • Year and Date: 2014-04-26
• [Presentation] The association between genetic variants identified by GWAS and prostate cancer risk and Mortality (2014)
  • Author(s): Motofumi Suzuki, Shigekatsu Maekawa, Yutaka Suzuki, Yutaka Kasuya, Tomio Arai, Makoto Suzuki, Moriaki Kato, Tetsuya Fujimura, Hiroshi Fukhara, Toru Nakagawa, Hiroaki Nishimatsu, Haruki Kume, Tadaichi Kitamura, and Yukio Homma
  • Organizer: The 29th Annual EAU (European Association of Urology) Congress
  • Place of Presentation: ストックホルム，スウェーデン
  • Year and Date: 2014-04-12
• [Presentation] TMPRSS2 Val160Met多型と前立腺癌発症リスク、病理学的所見、予後との相関 (2013)
  • Author(s): 鈴木基文、藤村哲也、福原浩、中川徹、榎本裕、西松寛明、久米春喜、粕谷豊、新井冨生、井川靖彦、北村唯一、本間之夫
  • Organizer: 第101回日本泌尿器科学会総会
  • Place of Presentation: さっぽろ芸術文化の館
• [Presentation] 遺伝子多型解析による前立腺癌の進展・予後予測の可能性 (2012)
  • Author(s): 鈴木基文
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: パシフィコ横浜
  • Invited
• [Presentation] 泌尿器癌におけるSNPsの意義 (2012)
  • Author(s): 鈴木基文
  • Organizer: 第77回日本泌尿器科学会東部総会
  • Place of Presentation: 東京ドームホテル
  • Invited
• [Presentation] The association between genetic variants identified by GWAS and prostate cancer risk and mortality
  • Author(s): Motofumi Suzuki, Shigekatsu Maekawa, Yutaka Suzuki, Yutaka Kasuya, Tomio Arai, Makoto Suzuki, Moriaki Kato, Tetsuya Fujimuta, Hiroshi Fukuhara, Toru Nakagawa, Hiroaki Nishimatsu, Haruki Kume, Tadaichi Kitamura, and Yukio Homma
  • Organizer: 29th Annual EAU (European Association of Urology) Congress
  • Place of Presentation: ストックホルム，スウェーデン
• [Presentation] GWASで特定された一塩基多型と日本人における前立腺癌発症リスクおよび予後との関連について（第2報）
  • Author(s): 鈴木基文、前川滋克、鈴木穣、粕谷豊、新井冨生、鈴木誠、加藤司顯、藤村哲也、福原浩、中川徹、久米春喜、北村唯一 、本間之夫
  • Organizer: 第102回 日本泌尿器科学会総会
  • Place of Presentation: 神戸市，神戸国際会議場
• [Presentation] TMPRSS2 Val160Met Polymorphism: Significant Association in Sporadic Prostate Cancer but not in Latent Cancer
  • Author(s): Motofumi Suzuki, Tomio Arai, Yutaka Kasuya, Tomio Arai, Moriaki Kato, Tadaichi Kitamura, and Yukio Homma
  • Organizer: 33rd Congress of the Societe Internationale D'Urologie
  • Place of Presentation: バンクーバー，カナダ
• [Presentation] TMPRSS2 Val160Met多型と前立腺癌
  • Author(s): 鈴木基文、藤村哲也、福原浩、中川徹、榎本裕、西松寛明、久米春喜、粕谷豊、新井冨生、井川靖彦、北村唯一、本間之夫
  • Organizer: 第101回 日本泌尿器科学会総会
  • Place of Presentation: 札幌市，さっぽろ芸術文化の館
• [Presentation] 前立腺ラテント癌：再考
  • Author(s): 鈴木基文、森川鉄平、新井冨生、粕谷豊、藤村哲也、福原浩、中川徹、西松寛明、久米春喜、井川靖彦、本間之夫
  • Organizer: 第78回 日本泌尿器科学会東部総会
  • Place of Presentation: 新潟市，朱鷺メッセ