Identification of mechanism of bladder cancer development with Ral associated molecular network
Project/Area Number |
24592386
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
|
Research Institution | Kyoto University |
Principal Investigator |
MATSUI Yoshiyuki 京都大学, 医学(系)研究科(研究院), 講師 (00582107)
|
Co-Investigator(Kenkyū-buntansha) |
OGAWA Osamu 京都大学, 医学研究科, 教授 (90260611)
大久保 和俊 京都大学, 医学(系)研究科(研究院), 講師 (20511877)
今村 正明 京都大学, 医学(系)研究科(研究院), 助教 (20594237)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 膀胱癌 |
Outline of Final Research Achievements |
We recognized that the activation of Ral induced by the down-regulation of RalGAPα2 had a possibility to be related to the bladder carcinogenesis, through suppressing Filamin A expression. We confirmed that the immunostaining intensity of Filamin A in human bladder cancer tissue was correlated with pathological aggressiveness and infiltration. Suppression of Filamin A led to reduced proliferation in bladder cancer cell lines, whereas we did not observe significant changes in cell migration and invasion. Filamin A did not affect the tumor growth and local invasion ability in subcutaneous and renal subcapsular xenograft models.
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Report
(4 results)
Research Products
(4 results)