The role of pCAM, papillary renal cell carcinoma-related factor for developing novel molecular pathologic classification and differentiation-inducing therapy
Project/Area Number |
24592396
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
|
Research Institution | Kochi University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
SHUIN Taro 高知大学, 教育研究部医療学系, 教授 (70128601)
KAMADA Masayuki 高知大学, 教育研究部医療学系, 講師 (90304683)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | 腎癌 / 細胞接着因子 / 乳頭状腎癌 |
Outline of Final Research Achievements |
Papillary cell adhesion molecule (pCAM) is a adhesion molecule of cell-cell and cell-basal lamina and expressing in only neuroendocrine tissue. We examined whether the pCAM was a key molecule of cell differentiation and pathological architecture in papillary renal cell carcinoma (RCC). A human RCC cell line, 786-O highly expressing pCAM was undifferentiated clear cell RCC. Downregulation of the pCAM expression made the 786-O tumor to be well differentiated papillary RCC in the kidney of athymic nude mouse. Re-expression of pCAM by site-directed mutagenesis method returned 786-O tumor to be undifferentiated clear cell RCC. We demonstrated the architectural transformation accompanied with changing epithelial mesenchymal transition (EMT) factors by PCR array 786O. In conclusions, the pCAM is a key molecule for papillary formation of RCC.
|
Report
(4 results)
Research Products
(1 results)