Ischemic factors in pathogenesis of interstitial cystitis

• Project/Area Number: 24592420
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: The University of Tokyo
• Principal Investigator: NOMIYA Akira 東京大学, 医学部附属病院, 臨床登録医 (30372379)
• Co-Investigator(Kenkyū-buntansha): NIIMI Aya 東京大学, 医学部附属病院, 助教 (00376451) ; IGAWA Yasuhiko 東京大学, 医学部附属病院, 特任教授 (40159588) ; HOMMA Yukio 東京大学, 医学部附属病院, 教授 (40165626) ; NISHIMATSU Hiroaki 東京大学, 医学部附属病院, 臨床研究医 (60251295)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 間質性膀胱炎 / 慢性炎症 / 動物モデル / 虚血 / 細胞・組織 / 膀胱

Outline of Final Research Achievements

Focusing on ischemic factors, we examined change in mRNA expressions in bladder mucosa of patients with interstitial cystitis and produce a rat model of chronic cystitis.

Research Products

• [Journal Article] Improvement of symptoms of aging in males by a preparation LEOPIN ROYAL containing aged garlic extract and other five of natural medicines - comparison with traditional herbal medicines (Kampo). (2014)
  • Author(s): Nishimatsu H, Kitamura T, Yamada D, Nomiya A, Niimi A, Suzuki M, Fujimura T, Fukuhara H, Nakagawa T, Enomoto Y, Kume H, Igawa Y, Homma Y.
  • Journal Title: Aging Male Volume: 17 Issue: 2 Pages: 112-116
  • DOI: 10.3109/13685538.2013.771328
  • Peer Reviewed / Open Access
• [Journal Article] 後期研修医がおさえておきたい泌尿器疾患TOP30、間質性膀胱炎 (2013)
  • Author(s): 野宮明
  • Journal Title: 泌尿器外科 Volume: 26 Pages: 246-260
• [Journal Article] 過活動膀胱と紛らわしい疾患・病態ー鑑別診断のポイント、膀胱の異常 間質性膀胱炎 (2013)
  • Author(s): 野宮明
  • Journal Title: 臨床泌尿器科 Volume: 67 Pages: 493-501
• [Journal Article] 実践マニュアル 膀胱のボツリヌス毒素療法 (2013)
  • Author(s): 野宮明
  • Journal Title: Urology Today Volume: 20 Pages: 147-151
• [Journal Article] Bladder pain syndrome(膀胱痛症候群） 間質性膀胱炎の治療とその限界 (2013)
  • Author(s): 野宮明
  • Journal Title: 排尿障害プラクティス Volume: 21 Pages: 221-228
• [Journal Article] Increased mRNA expression of genes involved in pronociceptive inflammatory reactions in bladder tissue of interstitial cystitis. (2013)
  • Author(s): Homma Y, Nomiya A, Tagaya M, Oyama T, Takagaki K, Nishimatsu H, Igawa Y.
  • Journal Title: J Urol. Volume: 190(5) Issue: 5 Pages: 1925-1931
  • DOI: 10.1016/j.juro.2013.05.049
  • Peer Reviewed
• [Journal Article] Adrenomedullin and angiopoietin-1 additively restore erectile function in diabetic rats: comparison with the combination therapy of vascular endothelial growth factor and angiopoietin-1. (2013)
  • Author(s): Hiroaki Nishimatsu, Akira Nomiya, et al.
  • Journal Title: Journal of sexual medicine Volume: 10 Issue: 7 Pages: 1707-1719
  • DOI: 10.1111/jsm.12177
  • Peer Reviewed
• [Journal Article] On- and post-treatment symptom relief by repeated instillations of heparin and alkalized lidocaine in interstitial cystitis. (2013)
  • Author(s): Nomiya A, Naruse T, Niimi A, Nishimatsu H, Kume H, Igawa Y, Homma Y.
  • Journal Title: International Journal of Urology Volume: 刊行予定 Issue: 11 Pages: 1118-1122
  • DOI: 10.1111/iju.12120
  • Peer Reviewed
• [Journal Article] Primary MALT lymphoma of the urinary bladder in the background of interstitial cystitis. (2012)
  • Author(s): Morita K, Nakamura F, Nannya Y, Nomiya A, Arai S, Ichikawa M, Maeda D, Homma Y, Kurokawa M.
  • Journal Title: Annals of Hematology Volume: 91 Pages: 1505-1506
  • Peer Reviewed
• [Journal Article] Admissions related to interstitial cystitis in Japan: an estimation based on the Japanese diagnosis procedure combination database. (2012)
  • Author(s): Sugihara T, Yasunaga H, Horiguchi H, Nakamura M, Nomiya A, Nishimatsu H, Matsuda S, Homma Y.
  • Journal Title: International Journal of Urology Volume: 19 Pages: 86-89
  • NAID: 10031184781
  • Peer Reviewed
• [Journal Article] Adrenomedullin Mediates Adipose Tissue-Derived Stem Cell-induced Restoration of Erectile Function in Diabetic Rats (2012)
  • Author(s): Nishimatsu H, Suzuki E, et al.
  • Journal Title: J Sex Med. Volume: 9 Issue: 2 Pages: 482-493
  • DOI: 10.1111/j.1743-6109.2011.02469.x
  • Peer Reviewed
• [Presentation] GENE EXPRESSION PATTERN OF TRANSIENT RECEPTOR POTENTIAL C IN PATIENTS WITH INTERSTITIAL CYSTITIS (2014)
  • Author(s): Akira Nomiya, Aya Niimi, Yasuhiko Igawa, Yukio Homma, et al.
  • Organizer: 44th annual meeting of the International Continence Society
  • Place of Presentation: Rio de Janeiro, Brazil
  • Year and Date: 2014-10-20 – 2014-10-24
• [Presentation] 間質性膀胱炎膀胱におけるTRPC発現の検討 (2014)
  • Author(s): 野宮 明、新美文彩、井川靖彦、本間之夫 ほか
  • Organizer: 第21回日本排尿機能学会総会
  • Place of Presentation: 岡山コンベンションセンタ―、岡山
  • Year and Date: 2014-09-17 – 2014-09-20
• [Presentation] 間質性膀胱炎の膀胱粘膜における親侵害受容作用に関連した遺伝子発現の検討 (2014)
  • Author(s): 野宮 明、新美文彩、井川靖彦、本間之夫 ほか
  • Organizer: 第102回日本泌尿器科学会総会
  • Place of Presentation: 神戸国際会議場、神戸
  • Year and Date: 2014-04-24 – 2014-04-27
• [Presentation] 間質性膀胱炎膀胱粘膜における TRPV2、TRPM2、NGF、CXCL9 の発現に 関する検討 (2014)
  • Author(s): 野宮 明
  • Organizer: 第13回日本間質性膀胱炎研究会
  • Place of Presentation: 東京、ステーションカンファランス
• [Presentation] 間質性膀胱炎に対するミラベグロンの有効性と安全性 (2013)
  • Author(s): 野宮 明
  • Organizer: 第20回日本排尿機能学会
  • Place of Presentation: 静岡、グランシップ
• [Presentation] 膀胱内注入療法 －ヘパリン、リドカイン、メイロンカクテルの使用経験- (2013)
  • Author(s): 野宮 明
  • Organizer: 第78回日本泌尿器科学会東部総会
  • Place of Presentation: 新潟、朱鷺メッセ
  • Invited
• [Presentation] Differently increased mRNA expression pattern of genes involved in pronociceptive inflammatory reactions in bladder tissue of classic and non-classic interstitial cystitis (2013)
  • Author(s): Akira Nomiya
  • Organizer: Annual meeting of International continence society, 2013
  • Place of Presentation: スペイン、バルセロナ
• [Presentation] 間質性膀胱炎の病態に迫る 間質性膀胱炎に対するボツリヌス毒素膀胱壁内注入療法 治療を通じて見えてきたもの (2012)
  • Author(s): 野宮明
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 間質性膀胱炎に対するA型ボツリヌス毒素膀胱壁内注入療法の治療成績 (2012)
  • Author(s): 野宮明
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: 横浜
• [Presentation] 間質性膀胱炎に対するA型ボツリヌス毒素膀胱壁内注入療法の有効性・安全性に関する検討 (2012)
  • Author(s): 野宮明
  • Organizer: 第19回日本排尿機能学会総会
  • Place of Presentation: 名古屋
• [Presentation] Interstitial cystitis associated with Sjogren syndrome (2012)
  • Author(s): Akira Nomiya
  • Organizer: 42nd Annual Meeting of the International Continece Society
  • Place of Presentation: Beijing, China