A novel genetically-engineered HSV-1 for treatment of chronic pain

• Project/Area Number: 24592421
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: The University of Tokyo
• Principal Investigator: FUKUHARA Hiroshi 東京大学, 医学部附属病院, 准教授 (20292948)
• Co-Investigator(Kenkyū-buntansha): ITOU Nobuko 東京大学, 医学部附属病院, 講師 (80332609)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 遺伝子治療 / 疼痛 / ヘルペスウイルス / 間質性膀胱炎

Outline of Final Research Achievements

Chronic pain is a serious medical condition. We constructed a novel genetically-engineered Herpes Simplex virus-1 (HSV-1) for treatment of chronic pain. The new virus, T3-X, expresses the morphine-like molecule even at latency. We tested the efficacy of T3-X in a mouse model of chronic neuropathic pain. Gene transfer and expression by HSV-1 may be suitable for developing treatments for chronic pain.

Research Products

• [Journal Article] Intermittent docetaxel chemotherapy is feasible for castration-resistant prostate cancer. (2015)
  • Author(s): Kume H, Kawai T, Nagata M, Azuma T, Miyazaki H, Suzuki M, Fujimura T, Nakagawa T, Fukuhara H, Homma Y
  • Journal Title: Molecular and Clinical Oncology Volume: 3 Pages: 303-307
  • Peer Reviewed / Open Access
• [Journal Article] Nocturia in men is a chaotic condition dominated by nocturnal polyuria (2015)
  • Author(s): Fujimura T, Yamada Y, Sugihara T, Azuma T, Suzuki M, Fukuhara H, Nakagawa T, Kume H, Igawa Y, Homma Y
  • Journal Title: Int J Urol. Volume: 22 Issue: 5 Pages: 496
  • DOI: 10.1111/iju.12710
  • Peer Reviewed
• [Journal Article] Adjuvant chemotherapy is possibly beneficial for locally advanced or node-positive bladder cancer (2015)
  • Author(s): Kanatani A, Nakagawa T, Kawai T, Naito A, Sato Y, Yoshida K, Nozaki K, Nagata M, Yamada Y, Azuma T, Suzuki M, Fujimura T, Fukuhara H, Nishimatsu H, Kume H, Igawa Y, Homma Y
  • Journal Title: Clin Genitourin Cancer Volume: 13 Issue: 2 Pages: e107-e112
  • DOI: 10.1016/j.clgc.2014.09.007
  • Peer Reviewed
• [Journal Article] Long-term caloric restriction in rats may prevent age-related impairment of in vitro bladder function. (2015)
  • Author(s): Ito H, Aizawa N, Fujita Y, Suzuki M, Fukuhara H, Homma Y, Kubota Y, Ito M, Andersson KE, Igawa Y
  • Journal Title: J Urol. Volume: 193 Issue: 6 Pages: 2123-2130
  • DOI: 10.1016/j.juro.2014.11.005
  • Peer Reviewed
• [Journal Article] Combination of docetaxel, ifosfamide and cisplatin (DIP) as a potential salvage chemotherapy for metastatic urothelial carcinoma (2015)
  • Author(s): Kakutani S, Fukuhara H, Taguchi S, Nagata M, Niimi A, Hattori M, Miyazaki H, Fujimura T, Nakagawa T, Kume H, Igawa Y, Homma Y
  • Journal Title: Jpn J Clin Oncol. Volume: 45 Issue: 3 Pages: 281
  • DOI: 10.1093/jjco/hyu201
  • Peer Reviewed
• [Journal Article] Selective inhibitory effect of imidafenacin and 5-hydroxymethyl tolterodine on capsaicin-sensitive C-fibers of the primary bladder mechanosensitive afferent nerves in the rat. (2015)
  • Author(s): Aizawa N, Ito H, Sugiyama R, Fujimura T, Suzuki M, Fukuhara H, Homma Y, Igawa Y
  • Journal Title: J Urol. Volume: 193 Issue: 4 Pages: 1423-1432
  • DOI: 10.1016/j.juro.2014.09.005
  • Peer Reviewed
• [Journal Article] A pilot study of autologous tumor lysate-loaded dendritic cell vaccination combined with sunitinib for metastatic renal cell carcinoma (2014)
  • Author(s): Matsushita H, Enomoto Y, Kume H, Nakagawa T, Fukuhara H, Suzuki M, Fujimura T, Homma Y, Kakimi K.
  • Journal Title: J Immunother Cancer. Volume: 2 Issue: 1 Pages: 30-30
  • DOI: 10.1186/s40425-014-0030-4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Risk factors for clinical metastasis in men undergoing radical prostatectomy and immediate adjuvant androgen deprivation therapy. (2014)
  • Author(s): Taguchi S, Fukuhara H, Kakutani S, Takeshima Y, Miyazaki H, Suzuki M, Fujimura T, Nakagawa T, Igawa Y, Kume H, Homma Y
  • Journal Title: Asian Pac J Cancer Prev. Volume: 15 Pages: 10729-10733
  • Peer Reviewed / Open Access
• [Journal Article] Ultra-early versus early salvage androgen deprivation therapy for post-prostatectomy biochemical recurrence in pT2-4N0M0 prostate cancer (2014)
  • Author(s): Taguchi S, Fukuhara H, Azuma T, Suzuki M, Fujimura T, Nakagawa T, Ishikawa A, Kume H, Igawa Y, Homma Y
  • Journal Title: BMC Urol. Volume: 14 Issue: 1 Pages: 81-86
  • DOI: 10.1186/1471-2490-14-81
  • Peer Reviewed / Open Access
• [Journal Article] Granulocyte macrophage colony-stimulating factor as a predictor of the response of metastatic renal cell carcinoma to tyrosine kinase inhibitor therapy. (2014)
  • Author(s): Yamada D, Matsushita H, Azuma T, Nakagawa T, Nagata M, Yamada Y, Suzuki M, Fujimura T, Fukuhara H, Kume H, Homma Y, Kakimi K
  • Journal Title: Mol Clin Oncol. Volume: 2 Pages: 1023-1027
  • Peer Reviewed / Open Access
• [Journal Article] Robot-assisted versus other types of radical prostatectomy: population-based safety and cost comparison in Japan, 2012-2013. (2014)
  • Author(s): Sugihara T, Yasunaga H, Horiguchi H, Matsui H, Fujimura T, Nishimatsu H, Fukuhara H, Kume H, Yu C, Kattan MW, Kiyohide F, Homma Y.
  • Journal Title: Cancer Sci. Volume: 105 Issue: 11 Pages: 1421-1426
  • DOI: 10.1111/cas.12523
  • Peer Reviewed
• [Journal Article] Improvement of symptoms of aging in males by a preparation LEOPIN ROYAL containing aged garlic extract and other five of natural medicines-comparison with traditional herbal medicines (Kampo) (2014)
  • Author(s): Nishimatsu H, Kitamura T, Yamada D, Nomiya A, Niimi A, Suzuki M, Fujimura T, Fukuhara H, Nakagawa T, Enomoto Y, Kume H, Igawa Y, Homma Y.
  • Journal Title: Aging Male Volume: 17 Issue: 2 Pages: 112
  • DOI: 10.3109/13685538.2013.771328
  • Peer Reviewed / Open Access
• [Journal Article] Long-term results of radical prostatectomy with immediate adjuvant androgen deprivation therapy for pT3N0 prostate cancer (2014)
  • Author(s): Sato YT, Fukuhara H, Suzuki M, Fujimura T, Nakagawa T, Nishimatsu H, Kume H, Morikawa T, Fukayama M, Homma Y.
  • Journal Title: BMC Urol. Volume: 14 Issue: 1 Pages: 13-18
  • DOI: 10.1186/1471-2490-14-13
  • Peer Reviewed / Open Access
• [Journal Article] Risk factors for septic shock in acute obstructive pyelonephritis requiring emergency drainage of the upper urinary tract (2014)
  • Author(s): Kamei J, Nishimatsu H, Nakagawa T, Suzuki M, Fujimura T, Fukuhara H, Igawa Y, Kume H, Homma Y.
  • Journal Title: Int Urol Nephrol. Volume: 46 Issue: 3 Pages: 493
  • DOI: 10.1007/s11255-013-0545-5
  • Peer Reviewed
• [Journal Article] Multiple primary malignant neoplasms of the glottis, renal pelvis, urinary bladder, oral floor, prostate, and esophagus in a Japanese male patient: A case report (2014)
  • Author(s): 2. Mukaiyama Y, Suzuki M, Morikawa T, Mori Y, Takeshima Y, Fujimura T, Fukuhara H, Nakagawa T, Nishimatsu H, Kume H, Homma Y.
  • Journal Title: World J Surg Oncol. Volume: 12 Issue: 1 Pages: 294-294
  • DOI: 10.1186/1477-7819-12-294
  • Peer Reviewed / Open Access
• [Journal Article] Intrascrotal dedifferentiated leiomyosarcoma originating from dartos muscle. (2014)
  • Author(s): Teshima T, Takahashi S, Nagamoto S, Miyazaki H, Nakagawa T, Fujimura T, Fukuhara H, Kume H, Homma Y.
  • Journal Title: Case Rep Urol. Volume: 84 Pages: 1929-1929
  • DOI: 10.1155/2014/841929
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic factors for metastatic urothelial carcinoma undergoing cisplatin-based salvage chemotherapy (2013)
  • Author(s): Taguchi S, Nakagawa T, Hattori M, Niimi A, Nagata M, Kawai T, Fukuhara H, Nishimatsu H, Ishikawa A, Kume H, Homma Y
  • Journal Title: Jpn J Clin Oncol. Volume: 43 Issue: 9 Pages: 923
  • DOI: 10.1093/jjco/hyt096
  • Peer Reviewed
• [Journal Article] Adrenomedullin and angiopoietin-1 additively restore erectile function in diabetic rats: comparison with the combination therapy of vascular endothelial growth factor and angiopoietin-1. (2013)
  • Author(s): Hiroaki Nishimatsu, Akira Nomiya, et al.
  • Journal Title: Journal of sexual medicine Volume: 10 Issue: 7 Pages: 1707-1719
  • DOI: 10.1111/jsm.12177
  • Peer Reviewed
• [Journal Article] Reduction of prostate cancer incidence by naftopidil, an α1 -adrenoceptor antagonist and transforming growth factor-β signaling inhibitor. (2013)
  • Author(s): Yamada D, Nishimatsu H, Kumano S, Hirano Y, Suzuki M, Fujimura T, Fukuhara H, Enomoto Y, Kume H, Homma Y
  • Journal Title: Int J Urol. Volume: 20 Issue: 12 Pages: 1220-1227
  • DOI: 10.1111/iju.12156
  • Peer Reviewed