Does Boturinum Toxin regulate TRP channel of the urinary bladder?
| Project/Area Number |
24592426
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
KUDO Shoji 山梨大学, 総合研究部, 医学研究員 (10313800)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Masayuki 山梨大学, 総合研究部, 教授 (80197318)
MIYAMOTO Tatsuya 山梨大学, 総合研究部, 助教 (80456459)
KIRA Satoru 山梨大学, 総合研究部, 診療助教 (10530115)
HANEDA Yaburu 山梨大学, 総合研究部, 助教 (20402068)
KOBAYASHI Hideki 山梨大学, 総合研究部, 助教 (50402053)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 下部尿路機能障害 / 過活動膀胱 / 排尿機能 / ＴＲＰイオンチャネル / VNUT / 尿路 / TRP / Piezo / Clock / 排尿障害 / 夜間頻尿 / PIEZO / Boturinus toxin / 膀胱上皮 / 機械受容体 / ATP |
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| Outline of Final Research Achievements |
ATP produced from urothelial cells have 2 functions. The 1st is to induce initial sensation of fullness of the urinary bladder, and 2nd is to improve compliance of the urinary bladder. We proved that urothelial cells can release ATP by exocytosis. This form of ATP release is regulated by VNUT (a vesicular nucleotide transporter). For example, VNUT-KO mice lack the initial sensation of fullness of the urinary bladder, reveal urinary frequent due to lower compliance of the urinary bladder than wild type, and do not urinate at similar locations as wild type. Among all parameter of urodynamic examination, only initial sensation of fullness of the urinary bladder shows a statistically significant negative correlation with quantitative expression of the urothelial cells.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Muscarinic Binding of the Novel Radioligand, [3H] Imidafenacin in the Hauman Bladder and Protid Gland2014
Author(s)
Akira Yoshida, Shiori Kuroda, Yoshiki Ito, Takashi Okura, Yoshiharu Deguchi, Atsushi Otsuka, Seiichiro Ozono, Masayuki Takeda
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Journal Title
J Pharmacol Sci, 124: 40-46, 2014.
Volume: 124
Pages: 40-46
Related Report
Peer Reviewed
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[Journal Article] A phase III, randomized, double-blind, placebo-controlled study of the β3-adrenoceptor agonist, mirabegron 50 mg once-daily, in Japanese patients with overactive bladder2014
Author(s)
Yamaguchi O, Marui H, Kakizaki H, Homma Y, Igawa Y, Takeda M
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Journal Title
BJU Int
Volume: 113
Pages: 951-960
Related Report
Peer Reviewed
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[Journal Article] Fesoterodine, its active metabolite and tolterodine bind selectively to muscarinic receptors in human bladder mucosa and detrusor muscle2013
Author(s)
Akira Yoshida, Yusuke Fuchihata, Shiori Kuraoka, Ayaka Osano, Atsushi Otsuka, Seiichiro Ozono, Masayuki Takeda, Keisuke Masuyama, Isao Araki, and Shizuo Yamada
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Journal Title
Urology
Volume: 81
Issue: 4
Pages: 920.e1-920.e5
DOI
Related Report
Peer Reviewed
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[Book] Incontinence 5th ed2014
Author(s)
Fry, C.H., Chako, S. Wacher S.de, Kanai, A.J., Takeda, M., Young, J.S.
Total Pages
560
Publisher
Health Publication Ltd.
Related Report
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