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Roles of mammalian cold shock proteins in spermatogenesis

Research Project

Project/Area Number 24592446
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionKyoto University

Principal Investigator

FUJITA JUN  京都大学, 医学(系)研究科(研究院), 教授 (50173430)

Co-Investigator(Renkei-kenkyūsha) NISHIYAMA Hiroyuki  筑波大学, 医学医療系, 教授 (20324642)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsストレス応答 / 精巣 / 炎症 / 体内時計 / 発がん / ストレス / 細胞・組織
Outline of Final Research Achievements

To clarify the functions of the cold shock protein Cirp in vivo, we produced cirp-knockout mice. We found that Cirp facilitates proliferation of undifferentiated. spermatogonia by inhibiting Dyrk1b. Cirp confers robustness to circadian oscillators through regulation of Clock expression. CIRP functions extracellularly as well and is a damage-associated molecular pattern molecule that promotes inflammatory responses in shock and sepsis. Cirp promotes the development of inflammation and carcinogenesis in liver and colon through regulating apoptosis and production of cytokines in inflammatory cells.
Thus, Cirp has both beneficial and detrimental effects in vivo.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (18 results)

All 2015 2014 2013 2012

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Acknowledgement Compliant: 2 results,  Open Access: 3 results) Presentation (4 results)

  • [Journal Article] Heat shock protein A4/Apg-2 is required for stem/progenitor cell maintenance in intestinal inflammation.2015

    • Author(s)
      Adachi T, Sakurai T, Kashida H, Mine H, Hagiwara S, Matsui S, Yoshida K, Nishida N, Watanabe T, Itoh K, Fujita J, Kudo M.
    • Journal Title

      Inflammatory Bowel Disease

      Volume: 21 Issue: 1 Pages: 31-39

    • DOI

      10.1097/mib.0000000000000244

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cold-inducible RNA-binding protein (Cirp) promotes the development of liver cancer.2015

    • Author(s)
      Sakurai T, Yada N, Watanabe T, Arizumi T, Hagiwara S, Ueshima K, Nishida N, Fujita J, Kudo M.
    • Journal Title

      Cancer Sci

      Volume: in press Issue: 4 Pages: 352-358

    • DOI

      10.1111/cas.12611

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heat shock protein A4 controls cell migration and gastric ulcer healing.2015

    • Author(s)
      Sakurai T, Kashida H, Hagiwara S, Nishida N, Watanabe T, Fujita J, Kudo M.
    • Journal Title

      Dig Dis Sci.

      Volume: 60 Issue: 4 Pages: 850-857

    • DOI

      10.1007/s10620-015-3561-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Expression of the oncoprotein gankyrin and phosphorylated retinoblastoma protein in human testis and testicular germ cell tumor.2014

    • Author(s)
      Satoshi Ando, Taeko Matsuoka, Koji Kawai, Shintaro Sugita, Akira Joraku, Takahiro Kojima, Takahiro Suetomi, Jun Miyazaki, Jun Fujita and Hiroyuki Nishiyama
    • Journal Title

      International Journal of Urology

      Volume: 21 Issue: 10 Pages: 992-998

    • DOI

      10.1111/iju.12484

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stress response protein Cirp links inflammation and tumorigenesis in colitis-associated cancer.2014

    • Author(s)
      Sakurai T, Kashida H, Watanabe T, Hagiwara S, Mizushima T, Iijima H, Nishida N, Higashitsuji H, Fujita J, Kudo M.
    • Journal Title

      Cancer Res

      Volume: 74 Issue: 21 Pages: 6119-6128

    • DOI

      10.1158/0008-5472.can-14-0471

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor necrosis factor and transforming growth factor beta regulate clock genes by controlling the expression of the cold inducible RNA - binding protein (CIRBP).2014

    • Author(s)
      Lopez MA, Meier D, Mueller AF, Franken P, Fujita J, Fontana A.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 289 Issue: 5 Pages: 2736-2744

    • DOI

      10.1074/jbc.m113.508200

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk factors for loss to follow-up during active surveillance of patients with Stage I seminoma.2014

    • Author(s)
      Endo T, Kawai K, Kamba T, Inai H, Uchida K, Miyazaki J, Kamoto T, Ogawa O, Nishiyama H.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 44(4) Issue: 4 Pages: 355-359

    • DOI

      10.1093/jjco/hyu001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hypothermia protects against fulminant hepatitis in mice by reducing reactive oxygen species production.2013

    • Author(s)
      Sakurai T, Kudo M, Watanabe T, Itoh K, Higashitsuji H, Arizumi T, Inoue T, Hagiwara S, Ueshima K, Nishida N, Fukumoto M, Fujita J.
    • Journal Title

      Dig Dis

      Volume: 31 Issue: 5-6 Pages: 440-6

    • DOI

      10.1159/000355242

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis.2013

    • Author(s)
      Qiang X*, Yang W-L, Wu R, Zhou M, Jacob A, Dong W, Kuncewitch M, Ji Y, Yang H, Wang H, Fujita J, Nicastro J, Coppa GF, Tracey KJ, Wang P.
    • Journal Title

      Nature Medicine

      Volume: 19 Issue: 11 Pages: 1489-1495

    • DOI

      10.1038/nm.3368

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-12013

    • Author(s)
      Y. Liu, H. Higashitsuji, K. Itoh, T. Sakurai, K. Koike, K. Hirota, M. Fukumoto, J. Fujita
    • Journal Title

      Biochemical and biophysical research communications

      Volume: 432 Issue: 1 Pages: 22-27

    • DOI

      10.1016/j.bbrc.2013.01.093

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice2012

    • Author(s)
      Masuda T, et al.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Issue: 27 Pages: 10885-108901

    • DOI

      10.1073/pnas.1121524109

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cold-inducible RNA-binding protein modulates circadian gene expression posttranscriptionally.2012

    • Author(s)
      Morf J, Rey G, Schneider K, Stratmann M, Fujita J, Naef F, Schibler U.
    • Journal Title

      Science

      Volume: 338 Issue: 6105 Pages: 379-383

    • DOI

      10.1126/science.1217726

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells.2012

    • Author(s)
      Sumitomo Y, Higashitsuji H, Higashitsuji H, Liu Y, Fujita T, Sakurai T, et al
    • Journal Title

      BMC Biotechnol

      Volume: 12 Issue: 1 Pages: 72-72

    • DOI

      10.1186/1472-6750-12-72

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] In situ differentiation of CD8αα T cells from CD4 T cells in peripheral lymphoid tissues2012

    • Author(s)
      Nambu Y., Hayashi T., Jang KJ, Aoki K., Mano H., Nakano K., Osato M., Takabashi K., Itoh K., Teramukai S., Komon T., Fujita J., Ito Y., Shimizu
    • Journal Title

      Scientific Reports

      Volume: 2 Issue: 1 Pages: 930-930

    • DOI

      10.1038/srep00642

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ほ乳類低温ショックタンパク質Cirpは炎症反応を増悪させる2014

    • Author(s)
      藤田潤
    • Organizer
      第9回臨床ストレス応答学会大会
    • Place of Presentation
      岡山市
    • Year and Date
      2014-11-01 – 2014-11-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 熱ショック蛋白質Apg-1 (Hspa4l/Osp94/HspH3)欠損によるマウス雄性不妊の機序2014

    • Author(s)
      藤田潤、伊藤克彦
    • Organizer
      第102回日本泌尿器科学会総会
    • Place of Presentation
      神戸市
    • Year and Date
      2014-04-24 – 2014-04-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 低温ショックタンパク質Cirpの生理的な機能の解析2013

    • Author(s)
      藤田潤
    • Organizer
      第101回日本泌尿器科学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] ほ乳類低温ショックタンパク質Cirpの生理機能2012

    • Author(s)
      藤田潤
    • Organizer
      臨床ストレス応答学会
    • Place of Presentation
      東京都
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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