Roles of mammalian cold shock proteins in spermatogenesis
Project/Area Number |
24592446
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
|
Research Institution | Kyoto University |
Principal Investigator |
FUJITA JUN 京都大学, 医学(系)研究科(研究院), 教授 (50173430)
|
Co-Investigator(Renkei-kenkyūsha) |
NISHIYAMA Hiroyuki 筑波大学, 医学医療系, 教授 (20324642)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | ストレス応答 / 精巣 / 炎症 / 体内時計 / 発がん / ストレス / 細胞・組織 |
Outline of Final Research Achievements |
To clarify the functions of the cold shock protein Cirp in vivo, we produced cirp-knockout mice. We found that Cirp facilitates proliferation of undifferentiated. spermatogonia by inhibiting Dyrk1b. Cirp confers robustness to circadian oscillators through regulation of Clock expression. CIRP functions extracellularly as well and is a damage-associated molecular pattern molecule that promotes inflammatory responses in shock and sepsis. Cirp promotes the development of inflammation and carcinogenesis in liver and colon through regulating apoptosis and production of cytokines in inflammatory cells. Thus, Cirp has both beneficial and detrimental effects in vivo.
|
Report
(4 results)
Research Products
(18 results)
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[Journal Article] Heat shock protein A4/Apg-2 is required for stem/progenitor cell maintenance in intestinal inflammation.2015
Author(s)
Adachi T, Sakurai T, Kashida H, Mine H, Hagiwara S, Matsui S, Yoshida K, Nishida N, Watanabe T, Itoh K, Fujita J, Kudo M.
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Journal Title
Inflammatory Bowel Disease
Volume: 21
Issue: 1
Pages: 31-39
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hypothermia protects against fulminant hepatitis in mice by reducing reactive oxygen species production.2013
Author(s)
Sakurai T, Kudo M, Watanabe T, Itoh K, Higashitsuji H, Arizumi T, Inoue T, Hagiwara S, Ueshima K, Nishida N, Fukumoto M, Fujita J.
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Journal Title
Dig Dis
Volume: 31
Issue: 5-6
Pages: 440-6
DOI
Related Report
Peer Reviewed
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[Journal Article] Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis.2013
Author(s)
Qiang X*, Yang W-L, Wu R, Zhou M, Jacob A, Dong W, Kuncewitch M, Ji Y, Yang H, Wang H, Fujita J, Nicastro J, Coppa GF, Tracey KJ, Wang P.
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Journal Title
Nature Medicine
Volume: 19
Issue: 11
Pages: 1489-1495
DOI
Related Report
Peer Reviewed
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[Journal Article] In situ differentiation of CD8αα T cells from CD4 T cells in peripheral lymphoid tissues2012
Author(s)
Nambu Y., Hayashi T., Jang KJ, Aoki K., Mano H., Nakano K., Osato M., Takabashi K., Itoh K., Teramukai S., Komon T., Fujita J., Ito Y., Shimizu
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Journal Title
Scientific Reports
Volume: 2
Issue: 1
Pages: 930-930
DOI
Related Report
Peer Reviewed
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