| Project/Area Number |
24592469
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
TATSUMI Keiji 京都大学, 医学(系)研究科(研究院), 非常勤講師 (10324633)
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| Co-Investigator(Kenkyū-buntansha) |
近藤 英治 京都大学, 医学(系)研究科(研究院), 講師 (10544950)
小西 郁生 京都大学, 医学(系)研究科(研究院), 教授 (90192062)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 妊娠高血圧腎症 / 酸化ストレス / statin / Nrf2 / 酸化LDL / Preeclampsia / LOX-1 |
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| Outline of Final Research Achievements |
Oxidative stress and inflammation are considered to be deeply involved in preeclampsia.
The activation of Nuclear factor erythroid 2-related factor2(Nrf2),a key transcriptional regulator against oxidative stress, was significantly suppressed in preeclamptic placentas. In vitro, Nrf2 activation was suppressed under hypoxic conditions, but it was augmented by statin. Nrf2 knockdown resulted in insufficient enhancement of antioxidant and cytoprotective genes under oxidative stress. In contrast, the Nrf2 signaling was augmented by statin. Reactive oxygen species(ROS) levels were observed treated with H2O2, while statin treatment significantly attenuated the H2O2-induced ROS levels.
Statin may have a potential therapeutic role for preeclampsia.
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