Molecular biological mechanisms of tumor growth in uterine leiomyoma
Project/Area Number |
24592524
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Yokohama City University |
Principal Investigator |
SATO Mikiko 横浜市立大学, 附属病院, 講師 (70326049)
|
Co-Investigator(Kenkyū-buntansha) |
MIYAGI Yohei 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), がん分子病態研究部門, 部門長 (00254194)
平原 史樹 横浜市立大学, 医学(系)研究科(研究院), 教授 (30201734)
|
Co-Investigator(Renkei-kenkyūsha) |
HIRAHARA Fumiki 横浜市立大学, 医学(系)研究科(研究院), 教授 (30201734)
MIYAGI Etsuko 横浜市立大学, 医学(系)研究科(研究院), 教授 (40275053)
NAGASHIMA Yoji 東京女子医科大学, 医学部, 教授 (10217995)
YAMANAKA Shoji 横浜市立大学, 附属病院, 准教授 (80264604)
HATA Masaharu 横浜市立大学, 医学(系)研究科(研究院), 教授 (60285145)
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Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 子宮筋腫 / エリスロポエチン / 血管成熟 / 多血症 / Erythropoietin / Angiopoietin |
Outline of Final Research Achievements |
Some uterine leiomyoma stay small, while others may enlarge tremendously. Myomatous erythrocytosis syndrome is a rare complication of uterine leiomyoma caused by erythropoietin (EPO) that is produced by tumor cells. We hypothesize that EPO may act as a factor that stimulates the enlargement of leiomyomas and assessed the EPO expression in leiomyomas and investigated the effects of EPO on the tumor growth. The mean EPO mRNA expression in the leiomyoma was higher than the corresponding normal myometrium by Real-time RT-PCR. A positive correlation of leiomyoma size and EPO mRNA expression was shown, suggesting the involvement of EPO in leiomyoma growth. Blood vessel maturity was also significantly increased in EPO-producing leiomyomas. As conclusions, EPO is produced in most of conventional leiomyomas and supports a model where EPO accelerates tumor growth, possibly by inducing vessel maturity. Our study suggests one possible mechanism by which some uterine leiomyomas reach a large size.
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Report
(4 results)
Research Products
(10 results)
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[Presentation] 閉経後に手術となった子宮筋腫および子宮肉腫症例の検討
Author(s)
太田幸秀, 上西園幸子, 小河原由貴, 佐藤 団, 長谷川哲哉, 小山麻希子, 横田奈朋, 沼崎令子, 佐藤美紀子, 宮城悦子, 榊原秀也, 平原史樹
Organizer
第124回関東連合産科婦人科学会総会
Place of Presentation
甲府富士屋ホテル(山梨県)
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