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Molecular biological mechanisms of tumor growth in uterine leiomyoma

Research Project

Project/Area Number 24592524
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionYokohama City University

Principal Investigator

SATO Mikiko  横浜市立大学, 附属病院, 講師 (70326049)

Co-Investigator(Kenkyū-buntansha) MIYAGI Yohei  地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), がん分子病態研究部門, 部門長 (00254194)
平原 史樹  横浜市立大学, 医学(系)研究科(研究院), 教授 (30201734)
Co-Investigator(Renkei-kenkyūsha) HIRAHARA Fumiki  横浜市立大学, 医学(系)研究科(研究院), 教授 (30201734)
MIYAGI Etsuko  横浜市立大学, 医学(系)研究科(研究院), 教授 (40275053)
NAGASHIMA Yoji  東京女子医科大学, 医学部, 教授 (10217995)
YAMANAKA Shoji  横浜市立大学, 附属病院, 准教授 (80264604)
HATA Masaharu  横浜市立大学, 医学(系)研究科(研究院), 教授 (60285145)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords子宮筋腫 / エリスロポエチン / 血管成熟 / 多血症 / Erythropoietin / Angiopoietin
Outline of Final Research Achievements

Some uterine leiomyoma stay small, while others may enlarge tremendously. Myomatous erythrocytosis syndrome is a rare complication of uterine leiomyoma caused by erythropoietin (EPO) that is produced by tumor cells. We hypothesize that EPO may act as a factor that stimulates the enlargement of leiomyomas and assessed the EPO expression in leiomyomas and investigated the effects of EPO on the tumor growth.
The mean EPO mRNA expression in the leiomyoma was higher than the corresponding normal myometrium by Real-time RT-PCR. A positive correlation of leiomyoma size and EPO mRNA expression was shown, suggesting the involvement of EPO in leiomyoma growth. Blood vessel maturity was also significantly increased in EPO-producing leiomyomas. As conclusions, EPO is produced in most of conventional leiomyomas and supports a model where EPO accelerates tumor growth, possibly by inducing vessel maturity. Our study suggests one possible mechanism by which some uterine leiomyomas reach a large size.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2015 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (9 results)

  • [Journal Article] Aberrant expression of erythropoietin in uterine leiomyoma: implications in tumor growth2015

    • Author(s)
      Ryoko Asano, Mikiko Asai-Sato, Yohei Miyagi, Taichi Mizushima, Makiko Koyama-Sato, Yoji Nagashima, Masataka Taguri, Hideya Sakakibara, Fumiki Hirahara, Etsuko Miyagi
    • Journal Title

      American Journal of Obstetrics and Gynecology

      Volume: 212 Issue: 2 Pages: 1-9

    • DOI

      10.1016/j.ajog.2015.02.016

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 閉経後手術となった子宮筋腫および子宮肉腫症例の検討2013

    • Author(s)
      上西園幸子,横田奈朋,太田幸秀,佐藤 団,小山麻希子,佐藤美紀子,宮城悦子,榊原秀也,平原史樹
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 当院における子宮筋腫合併妊娠症例の検討2013

    • Author(s)
      笠井絢子,今井雄一,持丸 綾,望月昭彦,倉澤健太郎,青木 茂,奥田美加,高橋恒男,平原史樹
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌プリンスホテル(北海道札幌市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 当院における子宮筋腫核出後妊娠の検討2013

    • Author(s)
      持丸 綾,今井雄一,笠井絢子,片山佳代,望月昭彦,倉澤健太郎,青木 茂,吉田 浩,奥田美加,高橋恒男,平原史樹
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌プリンスホテル(北海道札幌市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 子宮筋腫核出術後の筋腫再発の予測因子2013

    • Author(s)
      平田 豪,祐森明日菜,宇佐美友希,古野敦子,北川雅一,片山佳代,大島 綾,村瀬真理子,吉田 浩,平原史樹
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌プリンスホテル(北海道札幌市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 閉経後手術となった子宮筋腫および子宮肉腫症例の検討2013

    • Author(s)
      上西園幸子, 横田奈朋, 太田幸秀, 佐藤団, 小山麻希子, 佐藤美紀子, 宮城悦子, 榊原秀也, 平原史樹
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌プリンスホテル/ホテル札幌芸文館(北海道)
    • Related Report
      2012 Research-status Report
  • [Presentation] 当院における子宮筋腫合併妊娠症例の検討2013

    • Author(s)
      笠井絢子,倉澤健太郎,今井雄一,持丸綾、望月昭彦,青木茂,奥田美加,高橋恒男,平原史樹
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌プリンスホテル/ホテル札幌芸文館(北海道)
    • Related Report
      2012 Research-status Report
  • [Presentation] 当院における筋腫核出後妊娠の検討2013

    • Author(s)
      持丸綾,今井雄一,笠井絢子,片山佳代,望月昭彦,倉澤健太郎,青木茂,吉田浩,奥田美加,高橋恒男,平原史樹
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌プリンスホテル/ホテル札幌芸文館(北海道)
    • Related Report
      2012 Research-status Report
  • [Presentation] 子宮筋腫核出術後の筋腫再発の予後因子2013

    • Author(s)
      平田豪,祐森明日菜,宇佐見友希,古野敦子,北川雅一,片山佳代,大島綾,村瀬真理子,吉田浩,平原史樹
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌プリンスホテル/ホテル札幌芸文館(北海道)
    • Related Report
      2012 Research-status Report
  • [Presentation] 閉経後に手術となった子宮筋腫および子宮肉腫症例の検討

    • Author(s)
      太田幸秀, 上西園幸子, 小河原由貴, 佐藤 団, 長谷川哲哉, 小山麻希子, 横田奈朋, 沼崎令子, 佐藤美紀子, 宮城悦子, 榊原秀也, 平原史樹
    • Organizer
      第124回関東連合産科婦人科学会総会
    • Place of Presentation
      甲府富士屋ホテル(山梨県)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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