Development of prediction system of recurrence for endometrial cancer
| Project/Area Number |
24592531
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
KATAOKA Fumio 慶應義塾大学, 医学部, 助教 (40306824)
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| Co-Investigator(Kenkyū-buntansha) |
TSUDA Hiroshi 慶應義塾大学, 医学部, 講師 (00434880)
津田 浩史 慶應義塾大学, 医学部, 講師 (00423880)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 子宮体癌 / マイクロアレイ解析 / 再発予測 / 遊離DNA |
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| Outline of Final Research Achievements |
We analyzed the relationship between the expression profile pattern and prognosis of endometrial cancer, simultaneously in both cancer cells and associated stroma. We established a formula based on the gene expression profile of cancer and stroma to predict the recurrence using a logistic regression model. We estimated the accuracy of the formula using the 0.632 method. The estimated areas under the curve (AUC) of ROC in cancer and stroma, which were used to predict recurrence, were 0.800 and 0.758, respectively. The moderate accuracies to predict recurrence were achieved by the formula based on the gene expression profile of cancer and stroma. The established formula may predict the risk of recurrence more efficiently than conventional pathological diagnosis.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Simultaneous analysis of the gene expression profiles of cancer and stromal cells in endometrial cancer.2014
Author(s)
Iguchi Y, Ito YM, Kataoka F, Nomura H, Tanaka H, Chiyoda T, Hashimoto S, Nishimura S, Takano M, Yamagami W, Susumu N, Aoki D, Tsuda H.
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Journal Title
Genes, Chromosomes & Cancer
Volume: 53
Issue: 9
Pages: 725-37
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 子宮体癌特殊組織型の術前診断におけるunderdiagnosis 子宮体癌特殊組織型53例の術前診断の後方視的検討2013
Author(s)
桑波田 美智子, 山上 亘, 二宮 委美, 滝川 彩, 野村 弘行, 片岡 史夫, 冨永 英一郎, 鈴木 淳, 阪埜 浩司, 進 伸幸, 吉村 泰典, 青木 大輔
Organizer
第126回 関東連合産科婦人科学会
Place of Presentation
アクトシティ浜松
Related Report
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[Presentation] 子宮体癌の再発を予測できる間質遺伝子の発現に基づいた卵巣癌症例のグループ化2012
Author(s)
井口 蓉子, 津田 浩史, 片岡 史夫, 野村 弘行, 千代田 達幸, 平沢 晃, 冨永 英一郎, 山上 亘, 進 伸幸, 青木 大輔, 吉村 泰典
Organizer
第64回日本産科婦人科学会学術講演会
Place of Presentation
神戸ポートピアホテル，神戸国際展示場
Related Report
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