Reduction of capsular production of S.pneumoniae in children of acute otitis media
| Project/Area Number |
24592556
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Togawa Akihisa 和歌山県立医科大学, 医学部, 講師 (70305762)
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| Co-Investigator(Kenkyū-buntansha) |
Yamanaka Noboru 和歌山県立医科大学, 医学部, 教授 (10136963)
Ikeda Yorihiko 和歌山県立医科大学, 医学部, 講師 (20423949)
Ogami Masashi 和歌山県立医科大学, 医学部, 博士研究員 (90423946)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肺炎球菌 / フェーズ変化 / 莢膜 / 急性中耳炎 / 莢膜多糖体 |
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| Outline of Final Research Achievements |
Streptococcus pneumoniae, a leading cause of acute otitis media (AOM), undergoes spontaneous intra-strain phase variations such as transparent or opaque in colony morphology depending on the capsular productionsynthesis. Most isolates of S.pneumoniae are mixed population of transparent and Opaque colony phenotypes.The pneumococcus exhibit spontaneous phase variation between Transparent variants with thin capsule and Opaque variants with thick capsule。Sub-MIC levels of clarithromycin reduced the capsule of inter-cellular invaded pneumococci. The effect of clarithromycin against pneumococcal phase variation will suggest that clarithromycin would reduce the virulence of pneumococci
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Report
(5 results)
Research Products
(10 results)
