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Reduction of capsular production of S.pneumoniae in children of acute otitis media

Research Project

Project/Area Number 24592556
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionWakayama Medical University

Principal Investigator

Togawa Akihisa  和歌山県立医科大学, 医学部, 講師 (70305762)

Co-Investigator(Kenkyū-buntansha) Yamanaka Noboru  和歌山県立医科大学, 医学部, 教授 (10136963)
Ikeda Yorihiko  和歌山県立医科大学, 医学部, 講師 (20423949)
Ogami Masashi  和歌山県立医科大学, 医学部, 博士研究員 (90423946)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肺炎球菌 / フェーズ変化 / 莢膜 / 急性中耳炎 / 莢膜多糖体
Outline of Final Research Achievements

Streptococcus pneumoniae, a leading cause of acute otitis media (AOM), undergoes spontaneous intra-strain phase variations such as transparent or opaque in colony morphology depending on the capsular productionsynthesis. Most isolates of S.pneumoniae are mixed population of transparent and Opaque colony phenotypes.The pneumococcus exhibit spontaneous phase variation between Transparent variants with thin capsule and Opaque variants with thick capsule。Sub-MIC levels of clarithromycin reduced the capsule of inter-cellular invaded pneumococci. The effect of clarithromycin against pneumococcal phase variation will suggest that clarithromycin would reduce the virulence of pneumococci

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2015 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results)

  • [Journal Article] An application of outer membrane protein p6-specific enzyme-linked immunosorbent assay for detection of haemophilus influenzae in middle ear fluids and nasopharyngeal secretions.2013

    • Author(s)
      Hotomi M
    • Journal Title

      PLos One

      Volume: 8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Incidence survey of acute otitis media in children in Sado Island, Japan--Sado Otitis Media Study (SADOMS).2013

    • Author(s)
      Otsuka T
    • Journal Title

      PLos One

      Volume: 8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] PspA family distribution, antimicrobial resistance and serotype of Streptococcus pneumoniae isolated from upper respiratory tract infections in Japan.2013

    • Author(s)
      Hotomi M
    • Journal Title

      PLos One

      Volume: 8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Individual risk factors associated with nasopharyngeal colonization with Streptococcus pneumoniae and Haemophilus influenzae: a Japanese birth cohort study.2013

    • Author(s)
      Otsuka T
    • Journal Title

      Pedeatr Infect Dis J.

      Volume: 32 Pages: 709-714

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 肺炎球菌性中耳炎における病原性因子の発現と抗菌薬の影響.2015

    • Author(s)
      武田早織、平岡政信、山内一真、戸川彰久、保富宗城、山中昇
    • Organizer
      第3回日本耳鼻咽喉科感染症・エアロゾル学会
    • Place of Presentation
      札幌
    • Year and Date
      2015-09-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] Population Shift Of Infants' Nasopharyngeal Microbiota After Antibiotic Therapy2013

    • Author(s)
      Hiraoka M
    • Organizer
      The 8th International Symposium on Tonsils and Mucosal Barriers of the Upper Airways
    • Place of Presentation
      Zurich,Switzerland
    • Related Report
      2013 Research-status Report
  • [Presentation] 7価肺炎球菌結合型ワクチンによる急性中耳炎由来肺炎球菌のワクチンカバー率と予防効果の予測2012

    • Author(s)
      池田頼彦
    • Organizer
      日本化学療法学会西日本支部総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 急性中耳炎中における肺炎球菌フェーズ変化の検討2012

    • Author(s)
      保富宗城
    • Organizer
      日本化学療法学会西日本支部総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 上気道感染症における鼻咽腔肺炎球菌の量的変化2012

    • Author(s)
      小上真史
    • Organizer
      日本化学療法学会西日本支部総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Clinical efficacy of middle ear ventilation tube insertion against intractable acute otitis media2012

    • Author(s)
      Akihisa Togawa
    • Organizer
      The 9th international Conference on Cholesteatoma and Ear Surgery
    • Place of Presentation
      Nagasaki
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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