| Project/Area Number |
24592566
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
KOIZUKA IZUMI 聖マリアンナ医科大学, 医学部, 教授 (10211228)
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| Co-Investigator(Kenkyū-buntansha) |
MIKAMI Koshi 聖マリアンナ医科大学, 医学部, 助教 (20434409)
宮本 康裕 聖マリアンナ医科大学, 医学部, 講師 (70367340)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAMOTO Yasuhiro 聖マリアンナ医科大学, 医学部, 助教 (70367340)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Keywords | 耳科学 / 半規管－眼反射 / 耳石器－眼反射 / 可塑性 / 視覚刺激 / 利得制御機構 / tilt suppression / 前庭―眼反射 / 視覚―前庭矛盾刺激 / 耳石器―眼反射 / 偏垂直軸回転刺激 / 同期型視覚刺激装置 / 回転刺激装置 / 垂直軸回転刺激 / 半規管―眼反射 |
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| Outline of Final Research Achievements |
The vestibulo-ocular reflex (VOR) produces compensatory eye movements during head movements. The VOR consists of the semicircular-ocular reflex (ScOR) and the otolith-ocular reflex (OOR). The VOR is under adaptive control that corrects VOR performance when visual-vestibular mismatch arises during head movements. Most experiments concerning plasticity of the VOR have used the ScOR. In this study, using an off-vertical axis rotation, we studied whether the OOR showed plastic change by visuo-vestibular conflict stimulation or not. To modify the OOR, we used an adaptation paradigm for 20 minutes. All subjects failed to show adaptive plasticity after exposure to visuo-vestibular conflict stimulation for 20 minutes. Tilt suppression may play an important role to cancel the plastic change in the OOR.
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