Basic research of SIRT1 for treatment of allergic rhinitis

• Project/Area Number: 24592574
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Hokkaido University
• Principal Investigator: NAKAMARU Yuji 北海道大学, 大学病院, 講師 (20344509)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: アレルギー性鼻炎 / SIRT1 / IL-33 / 鼻アレルギー / ＩＬ-33

Outline of Final Research Achievements

In this study, we compared IL-33 expression at the inferior turbinate of the control and patients with allergic rhinisitis. IL-33 expression of the allergic rhinitis patients were up-regulated than those of the control. We next compared SIRT1 expressions of the inferior tubinates between the control and allergic rhinitis patients. The SIRT1 expressions of the allergic patients significantly lower than those of the controls.

Research Products

• [Journal Article] Oxidative stress regulates IL-4 gene expression in mast cells through the reduction of histone deacetylase (2015)
  • Author(s): Nakamaru, Y., Takagi, D., Homma, A., Hatakeyama, S., Fukuda, S.
  • Journal Title: Otolaryngol. Head Neck Surg. Volume: 152 Issue: 1 Pages: 48-52
  • DOI: 10.1177/0194599814559189
  • Peer Reviewed / Open Access
• [Journal Article] Characteristics and prognosis of hearing loss associated with Vogt-Koyanagi-Harada disease. (2014)
  • Author(s): Morita S, Nakamaru Y, Obara N, Masuya M, Fukuda S.
  • Journal Title: Audiol Neurootol Volume: 19 Issue: 1 Pages: 49-56
  • DOI: 10.1159/000356386
  • Peer Reviewed
• [Journal Article] Otolaryngologic Manifestations of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. (2012)
  • Author(s): Nakamaru Y, Takagi D, Oridate N, Homma A, Fukuda S.
  • Journal Title: Otolaryngol Head Neck Surg Volume: 146 Issue: 1 Pages: 119-12
  • DOI: 10.1177/0194599811424044
  • Peer Reviewed
• [Journal Article] Dysregulation of histone deacetylase and histone acetyltransferase in development of Wegener's granulomatosis. (2012)
  • Author(s): Takagi D, Nakamaru Y, Suzuki M, Fukuda S.
  • Journal Title: Ann Otol Rhinol Laryngol Volume: 121: Pages: 816-820
  • Peer Reviewed
• [Journal Article] Extranodal natural killer/T-cell lymphoma: a diagnostic dilemma. (2012)
  • Author(s): Yanagi H, Nakamura Y, Takagi D, Kubota K, Fukuda.
  • Journal Title: Rhinology Volume: 50 Pages: 325-331
  • Peer Reviewed
• [Journal Article] Giant frontal mucocele occurring 32 years after frontal bone fracture: a case report. (2012)
  • Author(s): Kamoshima Y, Terasaka S, Nakamaru Y, Takagi D, Fukuda S, Houkin K.
  • Journal Title: Case Rep Neurol Volume: 4 Issue: 1 Pages: 34-37
  • DOI: 10.1159/000336326
  • Peer Reviewed
• [Journal Article] 通年性アレルギー性鼻炎のエビデンス. (2012)
  • Author(s): 中丸裕爾
  • Journal Title: 鼻アレルギーフロンティア Volume: 12 Pages: 126-129
  • NAID: 40019445337
  • Peer Reviewed
• [Journal Article] :急性副鼻腔炎に対するLevofloxacin 500mg1日1回投与の治療効果. (2012)
  • Author(s): 高木 大, 中丸裕爾, 鈴木正宣, 福田 諭.
  • Journal Title: 耳喉頭頸 Volume: 84 Pages: 1021-1026
  • Peer Reviewed
• [Presentation] Oxidative stress regulates IL-4 gene expression in mast cells through the reduction of histone deacetylase (2014)
  • Author(s): Yuji Nakamaru, Dai Takagi , and Satoshi Fukuda
  • Organizer: AAO-HNSF Annual Meeting & OTO EXPO 2014
  • Place of Presentation: Orange County Convention Center（Orland,USA）
  • Year and Date: 2014-09-21 – 2014-09-24
• [Presentation] Preoperative magnetic resonance imagings for Sinonasal Inverted Papilloma (2013)
  • Author(s): Yuji Nakamaru, Dai Takagi, and Satoshi Fukuda
  • Organizer: 7th international symposium on recent advances in rhinosinusitis and nasal polyposis
  • Place of Presentation: くにびきメッセ（松江市）
  • Invited
• [Presentation] Nasolacrimal duct preserve technique for endoscopic medial maxillectomy (2013)
  • Author(s): Yuji Nakamaru, Dai Takagi , and Satoshi Fukuda
  • Organizer: 2nd meeting of european academy of ORL-HNS and CE ORL-HNS
  • Place of Presentation: Acropolis congress center(Nice France)
• [Presentation] ANCA関連血管炎症候群の耳、鼻症状 (2013)
  • Author(s): 中丸裕爾 高木大 福田諭
  • Organizer: 第63回日本アレルギー学会秋季学術大会
  • Place of Presentation: ホテルニューオータニ(東京都)
• [Presentation] Preoperative assessments of Sinonasal Inverted Papilloma (2013)
  • Author(s): Yuji Nakamaru, Dai Takagi, Yasushi Furuta, Keita Oikawa and Satoshi Fukuda
  • Organizer: 第52回日本鼻科学会総会・学術講演会
  • Place of Presentation: 福井フェニックスプラザ（福井市）
  • Invited
• [Presentation] アレルギー性鼻炎の診断と治療.
  • Author(s): 中丸裕爾
  • Organizer: 2012 年アレルギー週間記念講演会
  • Place of Presentation: 帯広厚生病院（帯広市）
  • Invited
• [Presentation] 3.0 Tesla MRIによる内反性乳頭腫茎部同定の試み.
  • Author(s): 中丸裕爾, 高木 大, 福田 諭
  • Organizer: 第51回日本鼻科学会
  • Place of Presentation: 幕張メッセ（千葉市）
• [Presentation] SIRT1蛋白の肥満細胞におけるIL-4産生調節.
  • Author(s): 中丸裕爾, 高木 大, 福田 諭
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場（大阪市）