Basic research of SIRT1 for treatment of allergic rhinitis
Project/Area Number |
24592574
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
|
Research Institution | Hokkaido University |
Principal Investigator |
NAKAMARU Yuji 北海道大学, 大学病院, 講師 (20344509)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | アレルギー性鼻炎 / SIRT1 / IL-33 / 鼻アレルギー / IL-33 |
Outline of Final Research Achievements |
In this study, we compared IL-33 expression at the inferior turbinate of the control and patients with allergic rhinisitis. IL-33 expression of the allergic rhinitis patients were up-regulated than those of the control. We next compared SIRT1 expressions of the inferior tubinates between the control and allergic rhinitis patients. The SIRT1 expressions of the allergic patients significantly lower than those of the controls.
|
Report
(4 results)
Research Products
(16 results)