Study of immunosuppressive mechanism in head and neck cancer and development of novel treatment
| Project/Area Number |
24592589
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Chiba University |
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Principal Investigator |
SAKURAI Daiju 千葉大学, 医学(系)研究科(研究院), 講師 (10375636)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 頭頸部癌 / 腫瘍免疫 / 骨髄性抑制細胞 / 免疫抑制 |
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| Outline of Final Research Achievements |
It has been reported that cancer cells induced myeloid-derived suppressor cells (MDSC) and suppressed anti-tumor immunity. In this study, we examined immune suppression in patients with head and neck cancer and tried to elucidate the underlying mechanism. Peripheral blood cells (PBCs) were obtained from patients with head and neck cancer and MDSCs were analyzed by flow cytometry. Granulocytic MDSC (G-MDSC) was accumulated in peripheral blood. There was no correlation between the percentage of G-MDSC and NKT cells. G-MDSC was depleted from PBCs and the proliferation of NKT cells upon alpha-Galactsylceramide stimulation was analyzed. Activation of NKT cells was not affected with or without G-MDSC. And, we examined the sensitivity to hydrogen peroxide (H2O2). Although T cell-death was elevated depend on H2O2 concentration, the effect on NKT cells was limited. NKT cells were resistant to H2O2, this result could explain the differential sensitivity to G-MDSC between T cells and NKT cells.
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Report
(4 results)
Research Products
(5 results)
