Analysis of malignant potential in high-grade salivary carcinoma

• Project/Area Number: 24592599
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kyushu University
• Principal Investigator: SHIRATSUCHI Hideki 九州大学, 医学(系)研究科(研究院), 研究員 (30398060)
• Co-Investigator(Kenkyū-buntansha): TORAHIKO Nakashima 九州大学, 医学研究科, 准教授 (00284505)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 唾液腺腫瘍 / 高悪性度癌 / 耳下腺癌 / 頭頸部癌 / 唾液腺癌 / 高悪性度

Outline of Final Research Achievements

In this study, we aimed to investigate the molecular mechanisms underlying the development of mucoepidermoid carcinoma (MEC). In 31 cases, we examined the MAML2 fusion status using reverse transcriptase polymerase chain reaction, and HER2 and EGFR status using immunohistochemistry and chromogenic in-situ hybridization. Our results suggest that HER2 or EGFR gene abnormality could play an important role in the development of high-grade MEC, and also in the progression from MAML2 fusion-positive low-/ intermediate-grade to high-grade in a subset of MEC. Furthermore, we suggest that high-grade MEC com- prises a heterogeneous group of tumours in terms of molecular pathogenesis, in particular MAML2 fusion status.

Research Products

• [Journal Article] Clinical relevance of Kuttner tumour and IgG4-related dacryoadenitis and sialoadenitis. (2014)
  • Author(s): Furukawa S1, Moriyama M, Kawano S, Tanaka A, Maehara T, Hayashida JN, Goto Y, Kiyoshima T, Shiratsuchi H, Ohyama Y, Ohta M, Imabayashi Y, Nakamura S.
  • Journal Title: Oral Dis Volume: 21(2) Issue: 2 Pages: 257-62
  • DOI: 10.1111/odi.12259
  • Peer Reviewed / Open Access
• [Journal Article] Inflammatory pseudotumor in head and neck. (2014)
  • Author(s): Segawa Y, Yasumatsu R, Shiratsuchi H, Tamae A, Noda T, Yamamoto H, Komune S
  • Journal Title: Auris Nasus Larynx Volume: 41(3) Pages: 2014-2014
  • Peer Reviewed / Open Access
• [Journal Article] Inflammatory pseudotumor in head and neck. (2013)
  • Author(s): Segawa Y, Shiratsuchi H
  • Journal Title: Auris Nasus Larynx. Volume: 41(3) Pages: 321-4
  • Peer Reviewed
• [Journal Article] Interferon Inducible IFI16 Expression in p16 Positive Squamous Cell Carcinoma of the Oropharynx. (2013)
  • Author(s): Yamauchi M, Shiratsuchi H
  • Journal Title: ISRN Otolaryngol Volume: 10 Pages: 263271-263271
  • Peer Reviewed
• [Journal Article] HER2 and EGFR gene copy number alterations are predominant in high-grade salivary mucoepidermoid carcinoma irrespective of MAML2 fusion status. (2013)
  • Author(s): Nakano T, Shiratsuchi H
  • Journal Title: Histopathology Volume: 63(3) Pages: 378-92
  • Peer Reviewed
• [Presentation] 唾液腺癌症例におけるEGFR抗原発現の検討 (2015)
  • Author(s): 中野 貴史、白土 秀樹
  • Organizer: 日本頭頸部外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-01-29 – 2015-01-30
  • Invited
• [Presentation] 唾液腺多形腺腫における再発様式の臨床病理学的検討 (2014)
  • Author(s): 白土 秀樹
  • Organizer: 日本耳鼻咽喉科学会総会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-05-13 – 2014-05-15
• [Presentation] 唾液腺多形腺腫における再発様式の臨床病理学的検討 (2013)
  • Author(s): 白土 秀樹
  • Organizer: 日本耳鼻咽喉科学会総会
  • Place of Presentation: 札幌
• [Presentation] 原発不明扁平上皮癌における口蓋扁桃病変の臨床病理学的検討 (2013)
  • Author(s): 白土秀樹 他
  • Organizer: 日本耳鼻咽喉科学会総会
  • Place of Presentation: 新潟