| Project/Area Number |
24592599
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TORAHIKO Nakashima 九州大学, 医学研究科, 准教授 (00284505)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 唾液腺腫瘍 / 高悪性度癌 / 耳下腺癌 / 頭頸部癌 / 唾液腺癌 / 高悪性度 |
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| Outline of Final Research Achievements |
In this study, we aimed to investigate the molecular mechanisms underlying the development of mucoepidermoid carcinoma (MEC). In 31 cases, we examined the MAML2 fusion status using reverse transcriptase polymerase chain reaction, and HER2 and EGFR status using immunohistochemistry and chromogenic in-situ hybridization. Our results suggest that HER2 or EGFR gene abnormality could play an important role in the development of high-grade MEC, and also in the progression from MAML2 fusion-positive low-/ intermediate-grade to high-grade in a subset of MEC. Furthermore, we suggest that high-grade MEC com- prises a heterogeneous group of tumours in terms of molecular pathogenesis, in particular MAML2 fusion status.
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