• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of malignant potential in high-grade salivary carcinoma

Research Project

Project/Area Number 24592599
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionKyushu University

Principal Investigator

SHIRATSUCHI Hideki  九州大学, 医学(系)研究科(研究院), 研究員 (30398060)

Co-Investigator(Kenkyū-buntansha) TORAHIKO Nakashima  九州大学, 医学研究科, 准教授 (00284505)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords唾液腺腫瘍 / 高悪性度癌 / 耳下腺癌 / 頭頸部癌 / 唾液腺癌 / 高悪性度
Outline of Final Research Achievements

In this study, we aimed to investigate the molecular mechanisms underlying the development of mucoepidermoid carcinoma (MEC). In 31 cases, we examined the MAML2 fusion status using reverse transcriptase polymerase chain reaction, and HER2 and EGFR status using immunohistochemistry and chromogenic in-situ hybridization. Our results suggest that HER2 or EGFR gene abnormality could play an important role in the development of high-grade MEC, and also in the progression from MAML2 fusion-positive low-/ intermediate-grade to high-grade in a subset of MEC. Furthermore, we suggest that high-grade MEC com- prises a heterogeneous group of tumours in terms of molecular pathogenesis, in particular MAML2 fusion status.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] Clinical relevance of Kuttner tumour and IgG4-related dacryoadenitis and sialoadenitis.2014

    • Author(s)
      Furukawa S1, Moriyama M, Kawano S, Tanaka A, Maehara T, Hayashida JN, Goto Y, Kiyoshima T, Shiratsuchi H, Ohyama Y, Ohta M, Imabayashi Y, Nakamura S.
    • Journal Title

      Oral Dis

      Volume: 21(2) Issue: 2 Pages: 257-62

    • DOI

      10.1111/odi.12259

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inflammatory pseudotumor in head and neck.2014

    • Author(s)
      Segawa Y, Yasumatsu R, Shiratsuchi H, Tamae A, Noda T, Yamamoto H, Komune S
    • Journal Title

      Auris Nasus Larynx

      Volume: 41(3) Pages: 2014-2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inflammatory pseudotumor in head and neck.2013

    • Author(s)
      Segawa Y, Shiratsuchi H
    • Journal Title

      Auris Nasus Larynx.

      Volume: 41(3) Pages: 321-4

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interferon Inducible IFI16 Expression in p16 Positive Squamous Cell Carcinoma of the Oropharynx.2013

    • Author(s)
      Yamauchi M, Shiratsuchi H
    • Journal Title

      ISRN Otolaryngol

      Volume: 10 Pages: 263271-263271

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] HER2 and EGFR gene copy number alterations are predominant in high-grade salivary mucoepidermoid carcinoma irrespective of MAML2 fusion status.2013

    • Author(s)
      Nakano T, Shiratsuchi H
    • Journal Title

      Histopathology

      Volume: 63(3) Pages: 378-92

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 唾液腺癌症例におけるEGFR抗原発現の検討2015

    • Author(s)
      中野 貴史、白土 秀樹
    • Organizer
      日本頭頸部外科学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-01-29 – 2015-01-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 唾液腺多形腺腫における再発様式の臨床病理学的検討2014

    • Author(s)
      白土 秀樹
    • Organizer
      日本耳鼻咽喉科学会総会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-05-13 – 2014-05-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 唾液腺多形腺腫における再発様式の臨床病理学的検討2013

    • Author(s)
      白土 秀樹
    • Organizer
      日本耳鼻咽喉科学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] 原発不明扁平上皮癌における口蓋扁桃病変の臨床病理学的検討2013

    • Author(s)
      白土秀樹 他
    • Organizer
      日本耳鼻咽喉科学会総会
    • Place of Presentation
      新潟
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi