Latent vulnerability of head and neck cancer-exploration and exploitation as a molecular target
| Project/Area Number |
24592600
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | National Hospital Organization, Kyushu Cancer Center |
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Principal Investigator |
MASUDA Muneyuki 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, その他 (90284504)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUI Masumi 名古屋市立大学, 大学院医学研究科 分子医学講座 分子毒性学分野, 教授 (30347158)
WAKASAKI Takahiro 九州大学, 医学研究院, 研究員 (10608871)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 癌幹細胞 / 頭頸部癌 / epigenetics / chromatin remodeling / CD44v9 / 癌進化 / 進化 / EMT |
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| Outline of Final Research Achievements |
1.Through the public data analyses of TCGA, we found that Sox2 is highly associated with the induction of pluripotency in head and neck cancer. We developed stable head and neck cancer cell lines, which stably overexpress Sox2 and are proceeding to the genome-wide analyses.
2. We evaluated the correlation between the expression of CD44v9, a promising cancer stem cell marker of solid tumors, and clinicopathlogical factors and prognosis using tumor samples obtained from patients who were treated with chemoradioselection strategy in the National Kyushu Cancer Center. It was clearly demonstrated that concurrent chemoradiation-induced CD44v9 expression was significantly associated with unfavorable prognosis of the patients (PlosOne). This is the first report that elucidated the prognostic value of CD44v9 in head and neck cancer.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Induction of CD44 variant 9-expressing cancer stem cells might attenuate the efficacy of chemoradioselection and worsens the prognosis of patients with advanced head and neck cancer2015
Author(s)
Aso T, Matsuo M, Kiyohara H, Taguchi K, Rikimaru F, Shimokawa M, Segawa Y, Higaki Y, Umeno H, Nakashima T, Masuda M.
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Journal Title
Plos One
Volume: 10
Issue: 3
Pages: e0116596-e0116596
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Prevalence of human papillomavirus in oropharyngeal cancer: a multicenter study in Japan2014
Author(s)
Hama T, Tokumaru Y, Fujii M, Yane K, Okami K, Kato K, Masuda M, Mineta H, Nakashima T, Sugasawa M, Sakihama N, Yoshizaki T, Hanazawa T, Kato H, Hirano S, Imanishi Y, Kuratomi Y, Otsuki N, Ota I, Sugimoto T, Suzuki S.
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Journal Title
Oncology
Volume: 87
Pages: 173-82
Related Report
Peer Reviewed
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