Drug response biomarker genes of ocular hypotensives
| Project/Area Number | 24592629 |
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Shimane University |
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Principal Investigator |
TANITO Masaki 島根大学, 医学部, 客員研究員 (30284037)
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| Co-Investigator(Kenkyū-buntansha) |
OHIRA Akihiro 島根大学, 医学部, 教授 (00169054)
HARA Katsunori 島根大学, 医学部, 助教 (00609323)
YASUYUKI Takai 島根大学, 医学部, 助教 (20397871)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed(Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost : ¥4,200,000、Indirect Cost : ¥1,260,000)
Fiscal Year 2014 : ¥650,000 (Direct Cost : ¥500,000、Indirect Cost : ¥150,000)
Fiscal Year 2013 : ¥2,080,000 (Direct Cost : ¥1,600,000、Indirect Cost : ¥480,000)
Fiscal Year 2012 : ¥2,730,000 (Direct Cost : ¥2,100,000、Indirect Cost : ¥630,000)
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| Keywords | 緑内障 |
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| Outline of Final Research Achievements |
To explore the genes that responsible for prostaglandin metabolism in ocular tissue, SNP analyses by using DMET (Drug Metabolizing Enzyme and Transporter)-Chip (Affymetrix) were performed among 10 latanoprost high responder and 10 latanoprost low responder subjects.
Drug response against tafulprost and travoprost was tested in about 200 subjects by the multicenter clinical study.
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Report
(4results)
Research Products
(5results)
