Drug response biomarker genes of ocular hypotensives

• Project/Area Number: 24592629
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Shimane University
• Principal Investigator: TANITO Masaki 島根大学, 医学部, 客員研究員 (30284037)
• Co-Investigator(Kenkyū-buntansha): OHIRA Akihiro 島根大学, 医学部, 教授 (00169054) ; HARA Katsunori 島根大学, 医学部, 助教 (00609323) ; YASUYUKI Takai 島根大学, 医学部, 助教 (20397871)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 緑内障

Outline of Final Research Achievements

To explore the genes that responsible for prostaglandin metabolism in ocular tissue, SNP analyses by using DMET (Drug Metabolizing Enzyme and Transporter)-Chip (Affymetrix) were performed among 10 latanoprost high responder and 10 latanoprost low responder subjects.
Drug response against tafulprost and travoprost was tested in about 200 subjects by the multicenter clinical study.

Research Products

• [Journal Article] Comparison of the toxicity profile of benzalkonium chloride-preserved tafluprost and SofZia-preserved travoprost applied to the ocular surface. (2015)
  • Author(s): 2. Kanamoto T, Kiuchi Y, Tanito M, Mizoue S, Naito T, Teranishi S, Hirooka K, Rimayanti U, Ocular Surface Dsease and Glaucoma Study Group
  • Journal Title: J Ocular Pharmacology and Therapeutics Volume: 3 Issue: 3 Pages: 156-64
  • DOI: 10.1089/jop.2014.0104
• [Presentation] Effects of benzalkonium chloride-preserved and SofZia-preserved topical prostaglandin analogues on the human ocular surface. (2013)
  • Author(s): Kiuchi Y, Tanito M, Mizoue S, Bana T
  • Organizer: American Academy of Ophthalmology Annual Meeting
  • Place of Presentation: New Orleans，米国
• [Presentation] タフルプロストおよびトラボプロストの１２週間点眼による自覚症状，製品満足度の検討 (2013)
  • Author(s): 1. 中村友美，金本尚志，小松直樹，谷戸正樹，寺西慎一郎，内藤知子，馬場哲也，廣岡一行，溝上志朗，木内良明，キーショットグループ
  • Organizer: 第67回日本臨床眼科学会
  • Place of Presentation: 横浜，パシフィコ横浜
• [Presentation] タフルプロストとトラボプロストの多施設無作為化比較試験－ラタノプロストからの切り替え (2013)
  • Author(s): 2. 金本尚志，小松直樹，谷戸正樹，寺西慎一郎，内藤知子，馬場哲也，廣岡一行，溝上志朗，木内良明，キーショットグループ
  • Organizer: 第67回日本臨床眼科学会
  • Place of Presentation: 横浜，パシフィコ横浜
• [Presentation] シンポジウムII 緑内障に関する最近のトピックス「緑内障遺伝子研究の現状」 (2012)
  • Author(s): 谷戸正樹
  • Organizer: 第32回日本眼薬理学会
  • Place of Presentation: ピアザ淡海（大津市）