Endovascular surgery for retinal diseases

• Project/Area Number: 24592674
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Yokohama City University
• Principal Investigator: KADONOSONO Kazuaki 横浜市立大学, 医学(系)研究科(研究院), 教授 (70275030)
• Co-Investigator(Kenkyū-buntansha): ARAKAWA Akira 横浜市立大学, 市民総合医療センター, 准教授 (30292337)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 血管内治療 / 網膜血管障害 / マイクロニードル

Outline of Final Research Achievements

We performed retinal endovascular surgery for such a serious retinal disease of 72 eyes with 72 patients with central retinal vein occlusion (CRVO). The type of CRVO were divided into 3 kinds of 30 eyes with ischemic, 34 eyes with intermediate and 8 eyes with non-ischemic. The surgical procedure is that a microneedle of 47 gauge is used to cannulate the central retinal vein and tissue plasminogen activator of 40μg/ml is injected for at least 3 minutes. 6 months after surgery, visual acuity (ETDRS letters charts), fundus photograph, fluorescein angiography and optic coherent tomography were performed. The results showed that visual acuity increased from 15 letters to 27 letters, and the retinal thickness decreased by 340μm. We concluded that endovascular surgery is feasible for retinal vessels and is proven to be effective for improvement of visual acuity.

Research Products

• [Journal Article] 網膜血管内治療 Retinal endovascular surgery (2014)
  • Author(s): 門之園 一明
  • Journal Title: あたらしい眼科 Volume: 31(8) Pages: 1131-1135
• [Journal Article] 網膜中心静脈閉塞症に対する網膜血管内治療－Retinal endovascular surgery for central retinal vein occlusion.－ (2013)
  • Author(s): 門之園 一明
  • Journal Title: 眼科 Volume: 55(13) Pages: 1611-1616
• [Journal Article] Endovascular cannulation with a microneedle for central retinal vein occlusion. (2013)
  • Author(s): Kadonosono K, Yamane S, Arakawa A, Inoue M, Yamakawa T, Uchio E, Yanagi Y, Amano S
  • Journal Title: JAMA Ophthalmology Volume: 131(6) Issue: 6 Pages: 783-786
  • DOI: 10.1001/jamaophthalmol.2013.2585
  • Peer Reviewed
• [Journal Article] 網膜血管内治療 (2013)
  • Author(s): 門之園 一明
  • Journal Title: 眼科手術 Volume: 26(2) Pages: 213-215
• [Presentation] Surgical management for refractory macular edema from CRVO (2015)
  • Author(s): 門之園 一明
  • Organizer: The 30th Asia-Pacific Academy of Ophthalmology Congress
  • Place of Presentation: Guangzhou Baiyun International Convention Center(Guangzhou, China)
  • Year and Date: 2015-04-03
  • Invited
• [Presentation] 静脈閉塞症に対する血管内治療の成果 (2014)
  • Author(s): 門之園 一明
  • Organizer: 第68回日本臨床眼科学会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県神戸市）
  • Year and Date: 2014-11-14
  • Invited
• [Presentation] Microneedleを用いるあたらしい硝子体手術手技 (2014)
  • Author(s): 門之園 一明
  • Organizer: 第9回京都大学臨床眼科討論
  • Place of Presentation: 京都大学（京都府京都市）
  • Year and Date: 2014-11-07
  • Invited
• [Presentation] 多数例のCRVOの網膜血管内治療成績 (2014)
  • Author(s): 門之園 一明
  • Organizer: Japan Macula Club第16回学術講演会
  • Place of Presentation: 蒲郡クラシックホテル（愛知県蒲郡市）
  • Year and Date: 2014-08-23
• [Presentation] 網膜血管内治療 (2013)
  • Author(s): 門之園 一明
  • Organizer: 第20回記念特別開催兵庫県網膜硝子体研究会
  • Place of Presentation: 神戸ポートピアホテル（神戸市）
  • Invited
• [Presentation] Retinal endovascular surgery for RVO. (2013)
  • Author(s): 門之園 一明
  • Organizer: The 8th Asia Pacific Vitreo-retina Society
  • Place of Presentation: 名古屋国際会議場(名古屋市）
  • Invited
• [Presentation] Micro-incision Vitrectomy (2013)
  • Author(s): 門之園 一明
  • Organizer: 7th Egyptian Vitreoretinal Sociey Annual International Conference
  • Place of Presentation: Cairo
  • Invited
• [Presentation] Retinal endovascular treatment for central retinal vein occlusion (2013)
  • Author(s): 門之園 一明
  • Organizer: 7th Egyptian Vitreoretinal Sociey Annual International Conference
  • Place of Presentation: Cairo
  • Invited
• [Presentation] Sheathotomy combined with retinal endovascular treatment for branch retinal vein occlusion (2013)
  • Author(s): 門之園 一明
  • Organizer: 7th Egyptian Vitreoretinal Sociey Annual International Conference
  • Place of Presentation: Cairo
  • Invited
• [Presentation] Retinal endovascular surgery with drug-administration for eyes with macula edema due to retinal vein occlusion (2013)
  • Author(s): 門之園 一明
  • Organizer: Vail Vitrectomy 2013
  • Place of Presentation: Vail
• [Presentation] 網膜中心静脈閉塞症に対する網膜血管内治療 (2013)
  • Author(s): 門之園 一明
  • Organizer: 第36回日本眼科手術学会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 次は何をする？網膜硝子体手術；より効率よく安全な手術 (2012)
  • Author(s): 門之園 一明
  • Organizer: 第51回日本網膜硝子体学会
  • Place of Presentation: 甲府
  • Invited
• [Book] Complications of Vitreo-Retinal Surgery (2013)
  • Author(s): 門之園 一明 他（Editor; Noemi Lois, David Wong)
  • Total Pages: 506
  • Publisher: Lippincott Williams & Wilkins
• [Patent(Industrial Property Rights)] 注射針 (2014)
  • Inventor(s): 門之園 一明、二村 英之
  • Industrial Property Rights Holder: 門之園 一明、二村 英之
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-12-17
  • Overseas
• [Patent(Industrial Property Rights)] 注射針 (2013)
  • Inventor(s): 門之園一明、二村英之
  • Industrial Property Rights Holder: 門之園一明、二村英之
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-265739
  • Filing Date: 2013-12-24