The development of new molecular target treatment drug for neuroblastoma using MYCN transgenic mouse
Project/Area Number |
24592698
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatric surgery
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Yoshiaki 九州大学, 大学病院, 准教授 (80345529)
TAGUCHI Tomoaki 九州大学, 医学研究院, 教授 (20197247)
KOHASHI Kenichi 九州大学, 医学研究院, 教授 (10529879)
MIYOSHI Kina 九州大学, 大学病院, 医員 (20621709)
TAJIRI Tatsuro 京都府立医科大学, 医学(系)研究科(研究院), 教授 (80304806)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 神経芽腫 / hedgehog signal / Hedgehog signal / MYCNトランスジェニックマウス / 分子標的治療 |
Outline of Final Research Achievements |
We used the MYCN transgenic mouse which was a neuroblastoma model mouse for determining the possibility of the new molecular target in the neuroblastoma. The tumor samples were obtained from homo and hetero MYCN transgenic mouse. The pathological examination was performed for homo and hetero MYCN transgenic mouse samples. And Hh signal proteins (Sonic Hh, GLi1, Patched) were dertermined using immunostaining method. H.E. stains of both samples were shown undifferentiated subtype of neuroblastoma and there were not differences between both groups. Sonic Hh, Patched was strong positive, but the GLi1 was negative in both group. From the results, there was not difference between two groups, even if the survival rate of each group were different. In the human neuroblastoma specimen, the GLi1 was strongly positive. However, in MYCN transgenic mouse, GLi1 was negative. Therefore the Hh signal activation was different between human neuroblastoma and MYCN trancegenic mouse.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] An augmented reality navigation system for pediatric oncologic surgery based on preoperative CT and MRI images.2013
Author(s)
Souzaki R, Ieiri S, Uemura M, Ohuchida K, Tomikawa M, Kinoshita Y, Koga Y, Suminoe A, Kohashi K, Oda Y, Hara T, Hashizume M, Taguchi T.
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Journal Title
J Pediatr Surg.
Volume: 48
Issue: 12
Pages: 2479-83
DOI
Related Report
Peer Reviewed
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[Journal Article] Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma2013
Author(s)
Rumbajan JM, Maeda T, Souzaki R, Mitsui K, Higashimoto K, Nakabayashi K, Yatsuki H, Nishioka K, Harada R, Aoki S, Kohashi K, Oda Y, Hata K, Saji T, Taguchi T, Tajiri T, Soejima H, Joh K.
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Journal Title
BMC Cancer
Volume: 13
Issue: 1
Pages: 608-619
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 新生児副腎部嚢胞性腫瘤の4例2014
Author(s)
宗崎良太、木下義晶、林田真、橋爪誠、田口智章
Organizer
第23回日本小児泌尿器科学会
Place of Presentation
横浜
Year and Date
2014-07-09 – 2014-07-11
Related Report
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[Presentation] The differences in the clinical and biological characteristic of neuroblastomas detected during and after a period of mass screening of six-month-old infants: A report from the Study Group for Pediatric Solid Tumors in the Kyushu Area, Japan2014
Author(s)
Ryota Souzaki, Yuhki Koga, Yagi Minoru, Fumio Yanai, Koichiro Ueda, Zaizen, Inomata Y, Yuichi Shinkoda, Matsufuji H, Suenobu S, Handa N, Oda Y, Hara T, Taguchi T.
Organizer
the 47th Annual meeting Pacific Association of Pediatric Surgerons
Place of Presentation
Banff, Canada.
Year and Date
2014-05-25 – 2014-05-29
Related Report
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[Presentation] AN AUGMENTED REALITY NAVIGATION SYSTEM FOR ENDOSCOPIC SURGERY FOR PEDIATRIC TUMORS BASED ON PREOPERATIVE CT OR MRI IMAGES2013
Author(s)
Ryota Souzaki, Satoshi Ieiri, Munenori Uemura, Morimasa Tomikawa, Yoshiaki Kinoshita, Yuhki Koga, Aiko Suminoe, Kenichi Kohashi, Yoshinao Oda, Toshiro Hara, Makoto Hashizume, Tomoaki Taguchi
Organizer
the 46th PAPS
Place of Presentation
Hunter Valley, Australia
Related Report
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[Presentation] Augmented reality navigation system for laparoscopic surgery for pediatric malignant tumor on preoperative CT image2013
Author(s)
Ryota Souzaki, Satoshi Ieiri, Munenori Uemura, Morimasa Tomikawa, Yoshiaki Kinoshita, Yuhki Koga, Aiko Suminoe, Kenichi Kohashi, Yoshinao Oda, Toshiro Hara, Makoto Hashizume, Tomoaki Taguchi
Organizer
International Pediatric Endosurgery Group 2013
Place of Presentation
北京
Related Report
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[Presentation] An augmented reality navigation system for pediatric surgery for tumors.2013
Author(s)
Ryota Souzaki, Satoshi Ieiri, Munenori Uemura, Morimasa Tomikawa, Yoshiaki Kinoshita, Yuhki Koga, Aiko Suminoe, Kenichi Kohashi, Yoshinao Oda, Toshiro Hara, Makoto Hashizume, Tomoaki Taguchi
Organizer
45th Congress of the International Society of Paediatric oncology (SIOP 2013)
Place of Presentation
香港
Related Report
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[Presentation] Augmented reality navigation system for laparoscopic surgery for small recurrence tumor based on preoperative CT image2012
Author(s)
Ryota Souzaki, Satoshi Ieiri, Munenori Uemura, Morimasa Tomikawa, Yoshiaki Kinoshita,Yuhki Koga, Aiko Suminoe, Kenichi Kohashi, Yoshinao Oda, Toshiro Hara, Makoto Hashizume, Tomoaki Taguchi
Organizer
SIOP asia 2012
Place of Presentation
Yogyakarta
Related Report
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