| Project/Area Number |
24592705
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
KOWATA Yuki 東北大学, 医学(系)研究科(研究院), 非常勤講師 (90623190)
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| Co-Investigator(Kenkyū-buntansha) |
TACHI Masahiro 東北大学, 大学院医学系研究科, 教授 (50312004)
KAWAKAMI Kazuyoshi 東北大学, 大学院医学系研究科, 教授 (10253973)
KANNO Emi 東北大学, 大学院医学系研究科, 講師 (10431595)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 創傷治癒学 / NKT細胞 / 感染 / ＮＫＴ細胞 |
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| Outline of Final Research Achievements |
Natural Killer T (NKT) cells, an unique lymphocyte with a potent regulatory ability in various inflammatory responses, produce IFN-γ and IL-4 upon stimulation with α-galactosylceramide (α-GalCer). However, it is not understood how this lymphocyte is involved in skin wound healing. In this study, we elucidated the role of NKT cells in the skin wound healing process. In Jα18KO mice lacking NKT cells, wound healing was impaired compared with wild-type (WT) mice. The adoptive transfer of liver mononuclear cells (LMNCs) from WT, but not from Jα18KO mice, resulted in the reversal of this impaired wound healing in Jα18KO mice. Administration of α-GalCer resulted in the acceleration of wound healing. These results indicate that NKT cells play important roles in wound healing.
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