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Explication of NKT cellular function in a chronic hurt and establishment of a new remedy by the control

Research Project

Project/Area Number 24592705
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Plastic surgery
Research InstitutionTohoku University

Principal Investigator

KOWATA Yuki  東北大学, 医学(系)研究科(研究院), 非常勤講師 (90623190)

Co-Investigator(Kenkyū-buntansha) TACHI Masahiro  東北大学, 大学院医学系研究科, 教授 (50312004)
KAWAKAMI Kazuyoshi  東北大学, 大学院医学系研究科, 教授 (10253973)
KANNO Emi  東北大学, 大学院医学系研究科, 講師 (10431595)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords創傷治癒学 / NKT細胞 / 感染 / NKT細胞
Outline of Final Research Achievements

Natural Killer T (NKT) cells, an unique lymphocyte with a potent regulatory ability in various inflammatory responses, produce IFN-γ and IL-4 upon stimulation with α-galactosylceramide (α-GalCer). However, it is not understood how this lymphocyte is involved in skin wound healing. In this study, we elucidated the role of NKT cells in the skin wound healing process. In Jα18KO mice lacking NKT cells, wound healing was impaired compared with wild-type (WT) mice. The adoptive transfer of liver mononuclear cells (LMNCs) from WT, but not from Jα18KO mice, resulted in the reversal of this impaired wound healing in Jα18KO mice. Administration of α-GalCer resulted in the acceleration of wound healing. These results indicate that NKT cells play important roles in wound healing.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2013 2012 Other

All Presentation (3 results) Remarks (1 results)

  • [Presentation] 創傷治癒過程におけるサイトカイン、ケモカイン産生とNKT細胞の関与2013

    • Author(s)
      丹野寛大, 川上和義, 鈴木愛子, 中山史子, 菅野恵美, 高木尚之, 石井恵子, 古和田雪, 丸山良子, 館 正弘
    • Organizer
      第43回日本創傷治癒学会
    • Place of Presentation
      別府
    • Related Report
      2013 Research-status Report
  • [Presentation] Role of invariant natural killer T cells in the skin wound healing2012

    • Author(s)
      Hiromasa Tanno, Kazuyoshi Kawakami, Emi Kanno, Denso Hayashi, Keiko Ishii, Ryoko Maruyama, Masahiro Tachi
    • Organizer
      4th Congress of the World Union of Wound Healing Societies
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] マウス皮膚創傷治癒過程とNatural Killer T細胞: IFN-γとIL-4の関与について2012

    • Author(s)
      丹野寛大, 川上和義, 立雅恵, 菅野恵美, 石井恵子, 林殿聡, 丸山良子, 館正弘
    • Organizer
      第42回日本創傷治癒学会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Remarks] 東北大学大学院医学系研究科 形成外科学分野

    • URL

      http://www.prs.med.tohoku.ac.jp/

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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