| Project/Area Number |
24592724
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Plastic surgery
|
|---|
| Research Institution | Kansai Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAKUDO Natsuko 関西医科大学, 医学部, 助教 (00509490)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | PRP / cytokine / electroporation / regenerative medicine / skin / skin ulcer / 電圧 / パルス |
|---|
| Outline of Final Research Achievements |
Skin and basis of skin ulcer have protective function not to permeate through them for medications and materials over 20kD molecules in the size. It is aimed to treat skin wounds and aging skin broadly, if medications and materials with larger molecule can be penetrated. In this time, how to penetrate 20-100kD growth factors minimally invasively trough the skin and the base of the skin ulcer using electroporation (EP method) is studied.
Any invasions in EP method, and permeating bFGF and PRP, which contains various growth factors, were investigated invasions. As comparing in voltages, in 80V light skin stimulation was observed only during induction. No skin and soft tissue damages remained. Cytokines penetrating the skin surface was confirmed, however, more detailed mechanisms will be investigated in the future.
|
