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The study of the repair mechanism by neuron and glial cell after central nervous system injury

Research Project

Project/Area Number 24592729
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionFukushima Medical University (2013-2014)
Yamagata University (2012)

Principal Investigator

ISEKI Ken  福島県立医科大学, 医学部, 教授 (70332921)

Co-Investigator(Kenkyū-buntansha) GOTO Kaoru  山形大学, 医学部, 教授 (30234975)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsグリオーシス / 凍結脳損傷 / プロテオグリカン / 脂質代謝酵素 / 肝障害 / 核内脂質代謝酵素 / コンドロイチン硫酸プロテオグリカン / ヘパラン硫酸プロテオグリカン / 中枢神経 / アストロサイト / 脳損傷 / ニューロン / グリア
Outline of Final Research Achievements

Transcription factor OASIS controls the production of proteoglycan in embryonic development, whereas Olig is a key factor of glial differentiation. However, detailed repair mechanism after brain injury remains unclear. We investigated the expression pattern of these transcription factors after brain injury. Results suggest that OASIS is involved in the regulatory mechanism of non-permissive environments for axonal outgrowth and that Olig genes regulate glial differentiation. The expression pattern of the relevant molecules remained unchanged in KO mice of diacylglycerol kinase, an enzyme responsible for the control of a lipid messenger diacylglycerol.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Invited: 1 results)

  • [Journal Article] Role of the N-terminal hydrophobic residues of DGKε in targeting the endoplasmic reticulum.2014

    • Author(s)
      Matsui H, Hozumi Y, Tanaka T, Okada M, Nakano T, Suzuki Y, Iseki K, Kakehata S, Topham MK, Goto K.
    • Journal Title

      Biochim Biophys Acta Molecular and Cell Biology of Lipids

      Volume: 1842 Issue: 10 Pages: 1440-1450

    • DOI

      10.1016/j.bbalip.2014.07.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An Outbreak of Carbon Monoxide Poisoning in Yamagata Prefecture Following the Great East Japan Earthquake2013

    • Author(s)
      Iseki K, Hayashida A, Shikama Y, Goto K, Tase C
    • Journal Title

      Asia Pac J of Med Toxicol

      Volume: 2 Pages: 37-41

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gliosis-specific transcription factor OASIS coincides with proteoglycan core protein genes in the glial scar and inhibits neurite outgrowth2012

    • Author(s)
      Iseki K, Hagino S, Nikaido T, Zhang Y, Mori T, Yokoya S, Hozumi Y, Goto K, Wanaka A, Tase C
    • Journal Title

      Biomedical Research

      Volume: 33 Pages: 345-353

    • NAID

      130004903839

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] NMDA receptor-mediated Ca(2+) influx triggers nucleocytoplasmic translocation of diacylglycerol kinase ζ under oxygen-glucose deprivation conditions, an in vitro model of ischemia, in rat hippocampal slices2012

    • Author(s)
      Suzuki Y, Yamazaki Y, Hozumi Y, Okada M, Tanaka T, Iseki K, Ohta N, Aoyagi M, Fujii S, Goto K.
    • Journal Title

      Histochem CellBiol

      Volume: 137 Issue: 4 Pages: 499-511

    • DOI

      10.1007/s00418-011-0907-y

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 一酵素ファミリーから見た生命現象2014

    • Author(s)
      後藤薫
    • Organizer
      日本解剖学会第60回東北・北海道連合支部学術集会
    • Place of Presentation
      福島学院大学
    • Year and Date
      2014-09-06 – 2014-09-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ζ型ジアシルグリセロールキナーゼ欠損マウスにおける臓器特異的糖脂質代謝異常と肥満について2014

    • Author(s)
      中野知之、後藤薫
    • Organizer
      日本解剖学会第60回東北・北海道連合支部学術集会
    • Place of Presentation
      福島学院大学
    • Year and Date
      2014-09-06 – 2014-09-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] ベータ型ジアシルグリセロールキナーゼはGluR2を介して線条体投射ニューロンの棘突起形成に関与する2014

    • Author(s)
      八月朔日泰和、後藤薫
    • Organizer
      日本解剖学会第60回東北・北海道連合支部学術集会
    • Place of Presentation
      福島学院大学
    • Year and Date
      2014-09-06 – 2014-09-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] An Overview of Hydrogen Sulfide Poisoning in Yamagata Prefecture2013

    • Author(s)
      Iseki K, Hayashida A, Yamazaki K, Tase C
    • Organizer
      12th Asia Pacific Association of Medical Toxicology
    • Place of Presentation
      ドバイ
    • Related Report
      2013 Research-status Report
  • [Presentation] Subcellular localization of Diacylglycerol kinase ε in transfected neurons2012

    • Author(s)
      Hirooki Matsui, Yasukazu Hozumi, Ken Iseki, Kaoru Goto
    • Organizer
      42th Annual Meeting of Neuroscience
    • Place of Presentation
      Convention Center, New Orleans, USA
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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