Examination of a different membranes on cytokine adsorption on circulating cytokine and search of a biomarker as a prognosticator in a sepsis rat continuous heamodiafiltration model

Research Project

Project/Area Number	24592732
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Emergency medicine
Research Institution	University of Yamanashi
Principal Investigator	HARII Norikazu 山梨大学, 総合研究部, 准教授 (80377522)
Co-Investigator(Kenkyū-buntansha)	MATSUDA Kenichi 山梨大学, 総合研究部, 教授 (60282480) GOTO Junko 山梨大学, 総合研究部, 助教 (60530102) YANAGISAWA Masahiko 山梨大学, 総合研究部, 助教 (90597022)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	血液浄化療法 / 敗血症性多臓器不全 / ラットエンドトキシンショックモデル / 急性血液浄化療法 / 敗血症 / 集中治療医学 / 急性腎不全
Outline of Final Research Achievements	Sepsis is a systemic inflammatory response syndrome caused by several infections. Excessive production of inflammatory mediators like cytokines and chemokines may develop multiple organ failure leading to death. Although hemodiafiltration is used as a renal replacement therapy, it is often considered for the treatment of septic renal failure with the concept of modulating immune response and ameliorating failure of other organs. Various membranes for hemodiafiltraion are commercialized and in each having their peculiar removal characteristics of the substance in blood. It is still unclear which membrane is suitable for the treatment of severe sepsis. We have been established hemodiafiltraion system for entdotoxin shock rat. We have studied the adsorption of influencing circulating levels of inflammatory mediators like cytokines for comparing several membranes and identified the polyarylate/polyethylsulfon(PEPA) membrane efficiently adsorbed the serum interleukin-6.