| Project/Area Number |
24592735
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Kiyoshi 岡山大学, 医歯薬学総合研究科, 教授 (40108171)
TAKAHASHI Toru 岡山県立大学, 保健福祉学部, 教授 (40252952)
MORIMATSU Hiroshi 岡山大学, 医歯薬学総合研究科, 教授 (30379797)
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| Research Collaborator |
OMORI Emiko 岡山大学, 医歯薬学総合研究科, 技術補佐員
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 集中治療医学 / 急性肝傷害 / 酸化ストレス / Nｒｆ２ / オートファジー / ヘムオキシゲナーゼ / Ｂａｃｈ１ / 四塩化炭素 / 集中治療学 / Bａｃｈ１ / Ｎｒｆ２ / Nrf2 / Bach1 |
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| Outline of Final Research Achievements |
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcriptional factor in the protection against oxidative stress. Nrf2 binds Map Recognition element (MARE) and regulates expression of antioxidant protein. In the present study, a transient and remarkable induction of Nrf2 mRNA was caused by oxidative stress in carbon tetrachloride (CCl4)-induced serious acute liver failure with phenobarbital pretreatment, a cytochrome P450 inducer. The serum ALT levels at 6 h after treatment were positively correlated with Nrf2 mRNA levels. Our findings suggest that Nrf2 mRNA expression may reflect the extent of oxidative tissue injury and it may be a novel marker of oxidative stress at acute hepatic failure.
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