Immunolocalization of aquaporin1 on the interfaces between tissues with different physical properties
| Project/Area Number |
24592761
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Takeyasu 新潟大学, 医歯学系, 教授 (40183941)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アクアポリン / 歯根膜 / 歯槽骨 / セメント質 / 運動器 / 密性結合組 / 密生結合組織 |
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| Outline of Final Research Achievements |
Aquaporin1 (AQP1) is a water channel protein previously identified in red blood cells and water transporting epithelia. The interfaces between tissues with different physical properties seem to be a harsh environment for the cells because of the continuous mechanical stresses caused by body action. In this study, AQP1 was found in specific cells on the interfaces between tissues which have different properties. These AQP1 positive cells on the interfaces showed poor cytoskeletons, and have big cell surface to cell volume ratios, and seem to belong to new cellular categories (different tissue connecting cells). In odontgenic cells, acellular cementblasts and alveolar bone surface cells express AQP1. It is suggested that AQP1 expressed in those stromal cells are involved in the movement of the cellular water molecules across the plasma membranes, when accompanying cellular deformations and movements, rather than water transportation.
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Report
(4 results)
Research Products
(3 results)
