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Destribution of vesicular aminoacid transporters during postnatal development in the trigeminal neurons

Research Project

Project/Area Number 24592762
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Morphological basic dentistry
Research InstitutionOsaka University

Principal Investigator

HONMA Shiho  大阪大学, 歯学研究科(研究院), 講師 (40372627)

Research Collaborator KADONO Kohki  
WAKISAKA Satoshi  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords小胞性アミノ酸輸送体 / シナプス関連タンパク / メルケル細胞 / ルフィニ神経終末 / 三叉神経中脳路核 / 三叉神経運動核 / 口腔の感覚受容器 / 三叉神経 / 機械受容器 / VGLUT / VGAT
Outline of Final Research Achievements

In this study, we focused on vesicular amino-acid transporters and synapse-related proteins (NR2A, NR2B and PSD95) in the brainstem and the peripheral nervous system.Though a synapse was not present, localization of vesicular amino-acid transporters, especially VGLUTs were found in periodontal Ruffini endings, Merkel cells in the oral mucosa, and free nerve endings in dental pulp. In the mesencephalic trigeminal nucleus and trigeminal motor nucleus, VGLUT and VGAD were observed. During the postnatal development, associated with a change of the jaw movement, the expression pattern of synapse-related proteins were observed between the mesencephalic trigeminal nucleus and the trigeminal motor nucleus.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (5 results) (of which Invited: 1 results)

  • [Journal Article] Lectin histochemistry of palatine glands in the developing rat2013

    • Author(s)
      Hakami ZW., Kitaura, H., Honma, S., Wakisaka, S., Takano-Yamamoto T
    • Journal Title

      Acta Histochemica

      Volume: (in press) Issue: 4 Pages: 596-605

    • DOI

      10.1016/j.acthis.2013.11.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lectin histochemistry of palatine glands in the developing rat2013

    • Author(s)
      Hakami Z, Kitaura H, Honma S, Wakisaka S, Takano-Yamamoto T.
    • Journal Title

      Acta Histochemica

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 歯根膜感覚の形態学2013

    • Author(s)
      本間志保
    • Journal Title

      歯界月報

      Volume: 738 Pages: 67-71

    • Related Report
      2012 Research-status Report
  • [Presentation] オトガイ神経損傷に伴う三叉神経節における非神経細胞の動態2014

    • Author(s)
      角野公紀、本間志保、脇坂 聡
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新生児ラットの口腔顎顔面領域の運動ニューロンにおけるPSD95タンパク質発現2014

    • Author(s)
      田中 輝、石濱孝二、脇坂 聡、本間志保、古郷幹彦
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] The morphological alteration of satellite cells and neurons in the trigeminal ganglion following different types of mental nerve injury2014

    • Author(s)
      Kohki Kadono, Shiho Honma, Satoshi Wakisaka
    • Organizer
      Kyungpook-Osaka University Internatioal Symposium
    • Place of Presentation
      Kyungpook National University School of Dentistry
    • Year and Date
      2014-05-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ラット咬筋神経損傷での三叉神経運動核におけるミクログリアの動態2014

    • Author(s)
      永谷俊介、伊藤章、角野公紀、本間志保、脇坂 聡
    • Organizer
      第68回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2014-05-07 – 2014-05-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] ラット口蓋粘膜におけるSNARE関連タンパクの局在2014

    • Author(s)
      本間志保、角野公紀、脇坂 聡
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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