| Project/Area Number |
24592762
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
HONMA Shiho 大阪大学, 歯学研究科(研究院), 講師 (40372627)
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| Research Collaborator |
KADONO Kohki
WAKISAKA Satoshi
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 小胞性アミノ酸輸送体 / シナプス関連タンパク / メルケル細胞 / ルフィニ神経終末 / 三叉神経中脳路核 / 三叉神経運動核 / 口腔の感覚受容器 / 三叉神経 / 機械受容器 / VGLUT / VGAT |
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| Outline of Final Research Achievements |
In this study, we focused on vesicular amino-acid transporters and synapse-related proteins (NR2A, NR2B and PSD95) in the brainstem and the peripheral nervous system.Though a synapse was not present, localization of vesicular amino-acid transporters, especially VGLUTs were found in periodontal Ruffini endings, Merkel cells in the oral mucosa, and free nerve endings in dental pulp. In the mesencephalic trigeminal nucleus and trigeminal motor nucleus, VGLUT and VGAD were observed. During the postnatal development, associated with a change of the jaw movement, the expression pattern of synapse-related proteins were observed between the mesencephalic trigeminal nucleus and the trigeminal motor nucleus.
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