Analysis of primary hematopoiesis in the adult mice
| Project/Area Number |
24592777
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NONAKA Naoko 昭和大学, 歯学部, 准教授 (20307052)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 造血 / 一次造血 / ビスプォスプォネート / 髄外造血 / 肝臓 / hemal node / 骨髄 / hamal node / bisphosphonate / 脾臓 / hamel node / グロビン |
|---|
| Outline of Final Research Achievements |
The treatment with nitrogen-containing bisphosphonate (NBP) and phenylhydrazine (PHZ) into mice enhanced the extramedullary hematopoiesis in the liver and induced the appearance of nuclear erythrocytes in the peripheral blood and hemal node like structure in the abdominal cavity. The gene analysis of hemoglobin showed the appearance of primary hematopoiesis in the bone marrow, liver and hemal node like structure inaddition to the secondary hematopoiesis. Our results first indicated the switch from the secondary to primary hematopoiesis in normal genomic animal model.
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Report
(5 results)
Research Products
(52 results)
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[Journal Article] NKG2D+ IFN-γ+ CD8+ T cells are responsible for palladium allergy.2014
Author(s)
Kawano M, Nakayama M, Aoshima Y, Nakamura K, Ono M, Nishiya T, Nakamura S, Takeda Y, Dobashi A, Takahashi A, Endo M, Ito A, Ueda K, Sato N, Higuchi S, Kondo T, Hashimoto S, Watanabe M, Watanabe M, Takahashi T, Sasaki K, Nakamura M, Sasazuki T, Narushima T, Suzuki R, Ogasawara K.
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Journal Title
PLoS One.
Volume: 9
Issue: 2
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access
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[Book] 歯の解剖学2014
Author(s)
近藤信太郎・中村雅典・松野昌展
Total Pages
160
Publisher
わかば出版
Related Report
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