Identification of the novel factors on the modulation of osteoclastogenesis
| Project/Area Number |
24592816
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAMI Masamichi 昭和大学, 歯学部歯科薬理学講座, 教授 (80307058)
YAMADA Atsushi 昭和大学, 歯学部口腔生化学講座, 講師 (50407558)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 破骨細胞 / 樹状細胞 / 分化 / 振り分け / 骨代謝 / RANKL / RANK / 遺伝子発現 / 細胞分化 / 遺伝子 / GM-CSF |
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| Outline of Final Research Achievements |
It is important for the elucidation of the bone diseases to investigate the novel factors and analyze the function during osteoclastogenesis. We found that signal transducers and activators of transcription (STAT) 5 is a important regulatory molecule for osteoclastogenesis. Similarly, overexpession of Batf, a member of AP-1 family, in macrophages, as osteoclast precursors, tended to fail to differentiate into osteoclasts. These results suggest that Stat5, as well as Batf may regulate osteoclastogenesis by suppressing osteoclastogenesis.
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Report
(5 results)
Research Products
(68 results)
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[Journal Article] R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts2012
Author(s)
Miyamoto A, Takami M, Matsumoto A, Mochizuki A, Yamada T, Tachi K, Shibuya I, Nakamach, T, Shioda S, Baba K, Inoue T, Miyamoto Y, Yim M, Kamijo R
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Journal Title
Cytotechnology
Volume: 64
Issue: 3
Pages: 331-339
DOI
Related Report
Peer Reviewed
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[Presentation] The effects of citalopram on masseter and neck muscle activities in mice2015
Author(s)
Nogawa Y, Mochizuki A, Katayama K, Ikeda M, Abe Y, Nakamura S, Nakayama K, Kiyomoto M, Kato T, Baba K, Wakabayashi N, Inoue T
Organizer
Society for Neuroscience 45th annual meeting
Place of Presentation
Chicago, U.S.A.
Year and Date
2015-10-18
Related Report
Int'l Joint Research
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[Presentation] Modulation of masseter activity by vigilance states and circadian rhythm2015
Author(s)
Mochizuki A, Katayama K, Kato T, Ikeda M, Nogawa Y, Nakamura S, Nakayama K, Kiyomoto M, Wakabayashi N, Baba K, Inoue T.
Organizer
第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会合同大会
Place of Presentation
神戸
Year and Date
2015-03-23
Related Report
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[Presentation] マウス咬筋および頸筋筋活動に対するシタロプラムの影響2014
Author(s)
野川泰葉, 望月文子, 片山慶祐, 池田美菜子, 安部友佳, 中村史朗, 中山希世美, 清本聖文, 加藤隆史, 馬場一美, 若林則幸, 井上富雄
Organizer
第8回三叉神経領域の感覚-運動統合機構研究会
Place of Presentation
軽井沢
Year and Date
2014-10-18
Related Report
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[Presentation] Masseter muscle activity during awake state, non-REM sleep and REM sleep in mice.2013
Author(s)
Katayama K, Mochizuki A, Kato T, Ikeda M, Nakayama K,Nakamura S,Yazawa I,Baba K, Inoue T
Organizer
Society for Neuroscience 43rd annual meeting
Place of Presentation
San DIego, USA
Related Report
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[Book] The New Frontiers in Research for Oral Cancer (Part I: Functions of Toll-like receptors in osteoclast differentiation induced by receptor activator of NF-kB ligand. )2013
Author(s)
Takami M, Miyamoto A, Matsumoto A, Mochizuki A, Tachi K, Baba K, Inoue T, Mijung Y, Shibuya I, Zhao B, Kamijo K.
Total Pages
209
Publisher
MARUZEN. CO. LTD.
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