| Project/Area Number |
24592816
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAMI Masamichi 昭和大学, 歯学部歯科薬理学講座, 教授 (80307058)
YAMADA Atsushi 昭和大学, 歯学部口腔生化学講座, 講師 (50407558)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 破骨細胞 / 樹状細胞 / 分化 / 振り分け / 骨代謝 / RANKL / RANK / 遺伝子発現 / 細胞分化 / 遺伝子 / GM-CSF |
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| Outline of Final Research Achievements |
It is important for the elucidation of the bone diseases to investigate the novel factors and analyze the function during osteoclastogenesis. We found that signal transducers and activators of transcription (STAT) 5 is a important regulatory molecule for osteoclastogenesis. Similarly, overexpession of Batf, a member of AP-1 family, in macrophages, as osteoclast precursors, tended to fail to differentiate into osteoclasts. These results suggest that Stat5, as well as Batf may regulate osteoclastogenesis by suppressing osteoclastogenesis.
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