The roles of HDAC and transcription factors in oral cancer development

• Project/Area Number: 24592839
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: KOBAYASHI Masanobu 北海道医療大学, 看護福祉学部, 教授 (80241321)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 低酸素 / 低栄養 / 転写因子 / 脱アセチル化酵素 / 低酸素環境 / PIAS3 / SIRT1 / IFN-beta / IRF3 / 低栄養環境

Outline of Final Research Achievements

In order to clarify the roles of surtuin in cancer cells, we examined how surtuin regulated the expression of hypoxia-induced genes, because we found that the expression of surtuin mRNA under hypoxic conditions.
We found that SIRT7 stimulated the expression of BCL6 and that SIRT7 increased the suppressive activity of transcription by BCL6.

Research Products

• [Journal Article] Hypoxia-Inducible Factors Activate CD133 Promoter through ETS Family Transcription Factors. (2013)
  • Author(s): Ohnishi S, Maehara O, Nakagawa K, Kameya A, Otaki K, Fujita H, Higashi R, Takagi K, Asaka M, Sakamoto N, Kobayashi M, Takeda H.
  • Journal Title: Plos One Volume: 20
  • NAID: 120005326763
  • Peer Reviewed
• [Journal Article] Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway. (2013)
  • Author(s): Goudarzi H, Iizasa H, Furuhashi M, Nakazawa S, Nakane R, Liang S, Hida Y, Yanagihara K, Kubo T, Nakagawa K, Kobayashi M, Irimura T, Hamada J.
  • Journal Title: Cancer Lett. Volume: 339 Pages: 82-92
  • Peer Reviewed
• [Journal Article] The nuclear protein Artemis promotes AMPK activation by stabilizing the LKB1-AMPK complex (2012)
  • Author(s): Nakagawa K, Uehata Y, Natsuizaka M, Kohara T, Darmanin S, Asaka M, Takeda H, Kobayashi M.
  • Journal Title: Biochem Biophys Res Commun. Volume: 427 Issue: 4 Pages: 790-795
  • DOI: 10.1016/j.bbrc.2012.09.140
  • Peer Reviewed