| Project/Area Number |
24592842
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nihon University |
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Principal Investigator |
MAENO Masao 日本大学, 歯学部, 教授 (60147618)
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| Co-Investigator(Kenkyū-buntansha) |
KAWATO Takayuki 日本大学, 歯学部, 准教授 (50386075)
TANABE Natsuko 日本大学, 歯学部, 准教授 (10409097)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯周病 / メタボリックシンドローム / バスピン / アンギオテンシンⅡ / 骨芽細胞 / 破骨細胞 / 転写因子 / マトリックス金属プロテアーゼ / 脂肪細胞 / MMP-1 / TIMP-1 / アディポカイン / アディポネクチン / GGT / 骨代謝 / アンギオテンシンII / ニコチン / アンジオテンシンII |
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| Outline of Final Research Achievements |
This study was conducted to clarify the effect of vaspin and angiotensin II on alveolar-bone absorption, after assuming the person infected with periodontitis and metabolic syndrome. Vaspin downregulates the osteoclastic differentiation in part and the production of proteases by inhibiting expression of the transcription factor NFATc1. Ang II stimulated the degradation process that occurs during extracellular matrix turnover in osteoid by increasing the production of MMP-3 and MMP-13 through MAPK signaling pathways via the AT1 receptor in osteoblasts. Ang II suppressed osteoblastic differentiation by altering the expression of osteogenesis-related transcription factors (Runx2, Msx2 and AJ18), and the function of osteogenesis via the AT1 receptor in osteoblasts.
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