Explication on the cellular biology relation which aimed at bone metabolism between periodontitis and metabolic syndrome
Project/Area Number |
24592842
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathobiological dentistry/Dental radiology
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Research Institution | Nihon University |
Principal Investigator |
MAENO Masao 日本大学, 歯学部, 教授 (60147618)
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Co-Investigator(Kenkyū-buntansha) |
KAWATO Takayuki 日本大学, 歯学部, 准教授 (50386075)
TANABE Natsuko 日本大学, 歯学部, 准教授 (10409097)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 歯周病 / メタボリックシンドローム / バスピン / アンギオテンシンⅡ / 骨芽細胞 / 破骨細胞 / 転写因子 / マトリックス金属プロテアーゼ / 脂肪細胞 / MMP-1 / TIMP-1 / アディポカイン / アディポネクチン / GGT / 骨代謝 / アンギオテンシンII / ニコチン / アンジオテンシンII |
Outline of Final Research Achievements |
This study was conducted to clarify the effect of vaspin and angiotensin II on alveolar-bone absorption, after assuming the person infected with periodontitis and metabolic syndrome. Vaspin downregulates the osteoclastic differentiation in part and the production of proteases by inhibiting expression of the transcription factor NFATc1. Ang II stimulated the degradation process that occurs during extracellular matrix turnover in osteoid by increasing the production of MMP-3 and MMP-13 through MAPK signaling pathways via the AT1 receptor in osteoblasts. Ang II suppressed osteoblastic differentiation by altering the expression of osteogenesis-related transcription factors (Runx2, Msx2 and AJ18), and the function of osteogenesis via the AT1 receptor in osteoblasts.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Low-intensity pulsed ultrasound-induced ATP increases bone formation via the P2X7 receptor in osteoblast-like MC3T3E1 cells.2015
Author(s)
Manaka S, Tanabe N, Kariya T, Naito M, Takayama T, Nagao M, Liu D, Ito K, Maeno M, Suzuki N, Miyazaki M
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Journal Title
FEBS Letters
Volume: 589
Issue: 3
Pages: 310-318
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] CRPは脂肪細胞による細胞外マトリックスタンパク代謝の分解系を促進する2015
Author(s)
中井久美子, 川戸貴行, 高橋由美, 梶 純也, 原田修成, 岡 仁, 森田十誉子, 山崎洋治, 富樫久美, 柏木 勝, 前野正夫
Organizer
第64回日本口腔衛生学会・総会
Place of Presentation
つくば国際会議場(茨城県つくば市)
Year and Date
2015-05-28 – 2015-05-29
Related Report
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[Presentation] 歯周病とメタボリックシンドローム発症との関連性-9年間のコホート研究-2014
Author(s)
森田十誉子, 山崎洋治, 藤春知佳, 森嶋清二, 石井孝典, 瀬戸美才, 西埜植規秀, 佐々木好幸, 川戸貴行, 本橋正史, 前野正夫
Organizer
第63回日本口腔衛生学会・総会
Place of Presentation
熊本市民会館(熊本県熊本市)
Year and Date
2014-05-30 – 2014-05-31
Related Report
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