Creating a diagnostic antibody and the search of the genes that define the pre-cancerous lesions of the oral cavity: from rats to humans
| Project/Area Number |
24592850
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Asahi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MOTOHIKO Nagayama 朝日大学, 歯学部, 准教授 (50298436)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 舌癌 / 発がん / 前癌病変 / 診断基準 / 上皮異形成 / モデル動物 / 境界病変 / 前癌病変マーカー / 抗体作成 / hnRNPK / 腫瘍マーカー |
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| Outline of Final Research Achievements |
Tongue cancer is to clarify the correlation between the gene mutation and tissue type in pre-cancerous lesions and borderline lesions of (oral cancer), and have found a new marker, which is an indicator of the diagnostic criteria and prognosis of pathological tissue diagnosis, epithelial dysplasia and epithelial lesion such as squamous cell carcinoma, we have established the objective diagnostic criteria of everyday struggling to cases.
According to tongue cancer model animal, we were able to the selection and establishment and functional analysis of genes that before defining the cancer lesion.To complete the antibody of the tumor marker of evaluation and serum in the pathological tissue of human precancerous lesions. A pre-cancerous lesion marker of establishment can be oral could be applied to immunostaining for cytology.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Establishment of a novel dwarf rat strain: cartilage calcification insufficient (CCI) rats.2015
Author(s)
Tanaka M, Minoru Watanabe M, Yokomi I, Matsumoto N, Sudo K, Satoh H, Igarashi T, Seki A, Amano H, Ohura K, Kakei R, Shibata S, Nagayama M, Tanuma J.
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Journal Title
Experimental Animals
Volume: 64
Pages: 1-25
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis.2014
Author(s)
Suwa H, Hirano M, Kawarada K, Nagayam M, Ehara M, Muraki T, Shisa H, Sugiyama A, Sugimoto M, Hiai H, Kitano M, Tanuma J.
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Journal Title
Oncology Reports
Volume: 31
Pages: 3-12
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis2013
Author(s)
Hirohiko Suwa, Jun-ichi Tanuma1, Masato Hirano, Motohiko Nagayama, Michiko Ehara, Tomonari Muraki, Hayase Shisa, Aiko Sugiyama, Masahiro Sugimoto, Hiroshi Hiai, Motoo Kitano.
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Journal Title
Cancer Science
Volume: 104
Pages: 1-10
Related Report
Peer Reviewed
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