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Development of mineral induced bioactive material

Research Project

Project/Area Number 24592878
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

ITO Shuichi  北海道医療大学, 歯学部, 准教授 (50382495)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Masanori  大阪大学, 歯学研究科(研究院), 准教授 (00337164)
IIJIMA Masahiro  北海道医療大学, 歯学部, 准教授 (20305915)
SAITO Takashi  北海道医療大学, 歯学部, 教授 (40265070)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords石灰化 / バイオアクティブ / 象牙質 / 象牙質石灰化 / バイオアクティブ材料
Outline of Final Research Achievements

Dental adhesive materials are widely used for composite resin treatment. However, there is a problem in long-term durability on dentin bond strength. In this study, experimental materials were used to create a resin composite containing 1.5% the calcium salts of 4-methacryloxyethyl trimellitate (CMET). We examined in vitro the mineral induction ability of CMET, compared with that of a model decalcified dentin matrix. We also examined the adhesion ability of HC and CMET to a dentin specimen by means of a micro-tensile bond test. In the micro-tensile bond test and the fracture modes after bond testing, experimental material containing CMET showed a high adhesive ability in 2 years water storage. Calcium ions were released from the CMET specimens. More mineralization occurred in the CMET group incubated for 24 hours. CMET combination coat material was excellent in the durability in dentine bond strength, and the effective thing was suggested in dental treatment.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (25 results)

All 2015 2014 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (16 results) (of which Invited: 7 results) Book (2 results)

  • [Journal Article] 新規接着性モノマーCMET配合シーリングコート材の象牙質接着性および再石灰化誘導能.2015

    • Author(s)
      甕富美子, 伊藤修一, Nomann NA, 斎藤隆史.
    • Journal Title

      日本歯科保存学会誌

      Volume: 58 Pages: 143-156

    • NAID

      130005068920

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of immersion of in solution of experimental toothpaste containing S-PRG filler on like-remineralization ability of etched enamel.2014

    • Author(s)
      Iijima M,Ito S, Nakagaki S, Kohda N, Muguruma T, Saito T, Mizoguchi I.
    • Journal Title

      Dent Mater J

      Volume: 33 Pages: 156-164

    • NAID

      130004519325

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 「歯質再石灰化治療の再前線」象牙質の再石灰化を誘導する材料2013

    • Author(s)
      伊藤修一, 斎藤隆史
    • Journal Title

      日歯理工誌

      Volume: 39 Pages: 212-219

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] コンポジットレジンVSグラスアイオノマーセメント2013

    • Author(s)
      伊藤修一, 斎藤隆史
    • Journal Title

      北医療大デンタルトピックス

      Volume: 44 Pages: 1-5

    • NAID

      40019930898

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efffects of the addition of fluoride to a 4-META/MMA-TBB based resin adhesive on fluoride release and cariostatic potential2013

    • Author(s)
      Iijima M, Ito S, Nakagaki S, Muguruma T, Saito T, Mizoguchi I
    • Journal Title

      Dent Mater J

      Volume: 32 Pages: 156-164

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of calcium salts of acidic monomers on mineral induction of phosphoprotein-immobilized to agarose beads2012

    • Author(s)
      Ito S,Iijima M, Motai F, Mizoguchi I, Saito T
    • Journal Title

      J Biomed Mater Res part A

      Volume: 100 Pages: 2760-2765

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of experimental acid/base conditioner on micro-tensile bond strength of 4-META/MMA-TBB resin to dentin after long-term water immersion2012

    • Author(s)
      Soeno K,Taira Y, Ito S
    • Journal Title

      Dent Mater J

      Volume: 31 Pages: 1-5

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] CaCl2添加4-META/MMA-TBBレジンの象牙質接着性及び象牙質再石灰化に対する影響2014

    • Author(s)
      伊藤修一, NOMANN Al, 斎藤隆史
    • Organizer
      第33回日本接着歯学会
    • Place of Presentation
      ニチイ学館、神戸市
    • Year and Date
      2014-12-13 – 2014-12-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effects of 4-META/MMA-TBB resin containing CaCl2 on dentin mineralization.2014

    • Author(s)
      NOMANN Al, 伊藤修一, 斎藤隆史
    • Organizer
      第141回日本歯科保存学会
    • Place of Presentation
      山形テルサ、山形市
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新規バイオアクティブセメントのイオン放出と抗菌性について2014

    • Author(s)
      近藤有紀, 植原治, 倉重圭史, 伊藤修一, 千葉逸朗, 齋藤隆史, 斎藤正人
    • Organizer
      第141回日本歯科保存学会
    • Place of Presentation
      山形テルサ、山形市
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新規バイオアクティブセメントの開発.2014

    • Author(s)
      伊藤修一, 斎藤隆史
    • Organizer
      第12回日本再生歯科学会
    • Place of Presentation
      徳島大学蔵本キャンパス、徳島市
    • Year and Date
      2014-08-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] S-PRGフィラー含有根管貼薬剤のイオン徐放性に関するin vitro での検討.2014

    • Author(s)
      白井要、伊藤修一、藤原正、斎藤隆史、古市保志.
    • Organizer
      第35回日本歯内療法学会
    • Place of Presentation
      朱鷺メッセ、新潟市
    • Year and Date
      2014-07-12 – 2014-07-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] PRGバリアコートが象牙質石灰化に与える影響2014

    • Author(s)
      伊藤修一, 甕富美子 NOMANN NA, 斎藤隆史
    • Organizer
      第140回日本歯科保存学会
    • Place of Presentation
      滋賀県立芸術劇場、大津市
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of atraumatic indirect pulp capping materials in dentin mineralization2013

    • Author(s)
      Ito S, Saito T
    • Organizer
      第9回世界歯内療法会議
    • Place of Presentation
      東京国際フォーラム、東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Possibility of bioactive materials containing Surface Pre-Reacted Glass-ionomer filler2013

    • Author(s)
      Ito S
    • Organizer
      The 24th Congress of international association of Pediatric dentsitry
    • Place of Presentation
      COEXソウル(大韓民国)、ソウル市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 新規モノマーCMET配合シーリングコート材の象牙質接着性への影響2013

    • Author(s)
      伊藤修一, 甕富美子 , NOMANN NA, 斎藤隆史
    • Organizer
      第138回日本歯科保存学会
    • Place of Presentation
      福岡国際会議場、福岡市
    • Related Report
      2013 Research-status Report
  • [Presentation] 新規モノマーCMET配合シーリングコート材の象牙質再石灰化への影響2013

    • Author(s)
      伊藤修一, 甕富美子 , NOMANN NA, 斎藤隆史
    • Organizer
      第11回日本再生歯科医学会
    • Place of Presentation
      日本大学理工学部駿河台キャンパス、東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Effect of bonding agents containing S-PRG filler in dentin mineralization2013

    • Author(s)
      Ito S, Iijima M, Mizoguchi I, Saito T
    • Organizer
      91th IADR
    • Place of Presentation
      米国シアトル
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Effect of Experimental Toothpaste Containing S-PRG Filler on Enamel Remineralization2013

    • Author(s)
      Kohda N, Iijima M, Ito S, Nakagaki S, Muguruma T, Saito T, Mizoguchi I
    • Organizer
      91th IADR
    • Place of Presentation
      米国シアトル
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Effects of several ions released from bioactive material on dentin remineralization.2012

    • Author(s)
      Ito S, Motai F, Saito T
    • Organizer
      Japan-China Dental Conference 2012
    • Place of Presentation
      中国成都市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 歯髄温存療法覆髄材が象牙質石灰化に及ぼす影響2012

    • Author(s)
      伊藤修一, 甕富美子, 斎藤隆史
    • Organizer
      第136回日本歯科保存学会
    • Place of Presentation
      沖縄宜野湾市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 歯髄温存療法覆髄材が象牙質石灰化に及ぼす影響2012

    • Author(s)
      伊藤修一, 甕富美子, 斎藤隆史
    • Organizer
      第10回日本再生歯科医学会
    • Place of Presentation
      神戸市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] イオン徐放性ボンディング材が象牙質石灰化に及ぼす影響2012

    • Author(s)
      伊藤修一, 甕富美子 , Nomann NA, 斎藤隆史
    • Organizer
      第31回日本接着歯学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] イラストで語る歯科医学最前線2013

    • Author(s)
      吉江弘正 監修、伊藤修一、斎藤隆史
    • Total Pages
      100
    • Publisher
      クインテッセンス出版
    • Related Report
      2013 Research-status Report
  • [Book] AT THE FOREFRONT Illustrated Topics in Dental Research and Clinical Practice . Chapter 14 Dentin Remineralization.2012

    • Author(s)
      Ito S, Saito T
    • Total Pages
      100
    • Publisher
      Quintessence international
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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