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Occlusal support and memory -Effect of oxidative stress-

Research Project

Project/Area Number 24592913
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthetic dentistry
Research InstitutionOkayama University

Principal Investigator

HARA Tetsuya  岡山大学, 医歯(薬)学総合研究科, 准教授 (60238160)

Co-Investigator(Kenkyū-buntansha) MINAGI Shogo  岡山大学, 医歯薬学総合研究科, 教授 (80190693)
KUROZUMI Akimasa  岡山大学, 医歯薬学総合研究科, 助教 (20599790)
OKA Morihiko  岡山大学, 医歯薬学総合研究科, 助教 (90335612)
ISHIMINE Chisa  岡山大学, 大学病院, 助教 (40581096)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords酸化ストレス / 咬合 / 記憶 / チオバルビツール酸反応物質 / Superoxide dismutase / 咬合支持
Outline of Final Research Achievements

The purpose of this study was to examine the relationship between memory learning and the loss and recovery of occlusal support, as an index of the oxidative stress in the brain.
Rats were divided to three groups and subjected to the passive avoidance experiment: 1) the extraction group which was extracted all maxillary molars, 2) the denture group wearing the experimental denture after molars extraction, and 3) control group.
Memory learning in the extraction group is reduced from an early stage as compared to the control group, and that in the denture group was decreased over time. Molar extraction group was under oxidative stress conditions as compared to the control group. Oxidation of lipids and antioxidant effects in the denture group was no difference between the control group. Therefore, it was suggested that oxidative stress would affect the defect of memory learning due to the loss of occlusal support.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2014 Other

All Presentation (3 results)

  • [Presentation] 咬合支持の喪失が記憶学習と酸化ストレスに及ぼす影響2014

    • Author(s)
      宮﨑貴子,原 哲也,伊志嶺知沙,坂本隼一,荒木大介,飯田祥与,清瀧優也,皆木省吾
    • Organizer
      日本老年歯科医学会第26回学術大会
    • Place of Presentation
      電気ビルみらいホール(福岡県・福岡市)
    • Year and Date
      2014-06-13 – 2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 咬合支持の喪失が記憶学習と酸化ストレスに及ぼす影響2014

    • Author(s)
      宮﨑貴子,原 哲也,伊志嶺知沙,荒木大介,飯田祥与,清瀧優也,皆木省吾
    • Organizer
      日本老年歯科医学会第25回学術大会
    • Place of Presentation
      電気ビルみらいホール
    • Related Report
      2013 Research-status Report
  • [Presentation] Contralateral Hippocampal Pyramidal Cells is Reduced by Unilateral Tooth Extraction

    • Author(s)
      Hara T,Miyazaki T,Sakamoto S,Iida S,Araki D,Kurozumi A,Kuroda-Ishimine C,Oka M, Minagi S
    • Organizer
      International Association for Dental Research
    • Place of Presentation
      Saettle, USA
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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