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Development of a high-performance nanobiological interface control method for bioactive surface modification of hydroxyapatite with UV/ozone

Research Project

Project/Area Number 24592915
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthetic dentistry
Research InstitutionHiroshima University

Principal Investigator

ABE Yasuhiko  広島大学, 医歯薬保健学研究院, 准教授 (00253097)

Co-Investigator(Kenkyū-buntansha) HIRATA Isao  広島大学, 大学院医歯薬保健学研究院, 助教 (40346507)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords生体材料 / セラミックス / ナノバイオ / 表面・界面物性 / アパタイト / 紫外線
Outline of Final Research Achievements

The purpose of this study was to evaluate the effect of UV/ozone treatment on hydroxyapatite and establish the high-performance nanobiological interface control method for bioactive surface modification of hydroxyapatite. The 5-minute UV/ozone treatment could validate for the surface decontamination, the improvement and 7-day maintenance of wettability, and the acceleration of the adhesion and proliferation of MC3T3-E1 cells. Therefore, the UV/ozone treatment for the interface control between hydroxyapatite and bone was developed.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Osteoclast response to bioactive surface modification of hydroxyapatite2014

    • Author(s)
      1.Okazaki, Y., Abe, Y., Yasuda, K., Hiasa, K. and Hirata, I.
    • Journal Title

      Open Journal of Stomatology

      Volume: 4 Issue: 07 Pages: 340-344

    • DOI

      10.4236/ojst.2014.47047

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bioactive surface modification of hydroxyapatite2013

    • Author(s)
      Abe, Y., Okazaki, Y., Hiasa, K., Yasuda, K., Nogami, K. Mizumachi, W. and Hirata, I.
    • Journal Title

      BioMed Research International

      Volume: 2013 Pages: 626452-626452

    • DOI

      10.1155/2013/626452

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] ハイドロキシアパタイトの生体活性化表面改質への紫外線オゾン処理の効果2014

    • Author(s)
      保田啓介,岡﨑洋平,日浅 恭,小林昌子,阿部泰彦,津賀一弘
    • Organizer
      第123回日本補綴歯科学会学術大会
    • Place of Presentation
      仙台
    • Year and Date
      2014-05-24 – 2014-05-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 表面活性化ハイドロキシアパタイトに対する骨芽細胞の応答解析

    • Author(s)
      岡﨑洋平,阿部泰彦,日浅 恭,赤川安正
    • Organizer
      第41回日本口腔インプラント学会学術大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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