Elucidation of chronic periodontitis tissue destruction and tissue remodeling mechanism as seen from the periodontal tissue stem cells
| Project/Area Number | 24592965 |
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORIKAWA Satoru 慶應義塾大学, 医学部, 助教 (00424169)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed(Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost : ¥4,100,000、Indirect Cost : ¥1,230,000)
Fiscal Year 2014 : ¥1,950,000 (Direct Cost : ¥1,500,000、Indirect Cost : ¥450,000)
Fiscal Year 2013 : ¥1,820,000 (Direct Cost : ¥1,400,000、Indirect Cost : ¥420,000)
Fiscal Year 2012 : ¥1,560,000 (Direct Cost : ¥1,200,000、Indirect Cost : ¥360,000)
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| Keywords | 歯周組織 / 再生医療 / 再生医学 / 間葉系幹細胞 / 神経堤細胞 / iPS細胞 / 新規歯周組織再生療法 / 実験的慢性歯周炎 / 組織再生 / 歯周組織幹細胞 |
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| Outline of Final Research Achievements |
Homeostasis of periodontal tissue have been made by local periodontal ligament cells and alveolar bone cells. It has been reported that stem cell-like cells from the trunk migrate to periodontal tissue, and contributes to the regeneration and repair of periodontal tissue. Furthermore, these cells express the specific marker (PDGFRa) of bone marrow mesenchymal stem cells. Mesenchymal stem cells present in the periodontal tissue. The developmental origin of periodontal tissue is neural crest cells. We tried to induce neural crest cells from human iPS cells. It is the goal of this study aims to connect to periodontal tissue regeneration therapy , and obtained the following results. (1) We succeeded establishment of a method to generate human iPS cells derived human neural crest cells. (2) We conformed induced neural crest cells differentiated into osteo, chondro, fat, and peripheral nerve cells. (3) We verified that induced neural crest cells have highest migration potency.
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Report
(4results)
Research Products
(39results)
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[Journal Article] Homeodomain transcription factor meis1 is a critical regulator of adult bone marrow hematopoiesis.2014
Author(s)
Ariki R, Morikawa S, Mabuchi Y, Suzuki S, Nakatake M, Yoshioka K, Hidano S, Nakauchi H, Matsuzaki Y, Nakamura T, Goitsuka R.
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Journal Title
PLoS One.
Volume : 9
Pages : 87646-87646
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] 糖尿病患者における歯周病原細菌の血清抗体価に関する調査2014
Author(s)
太田 淳也, 深谷 千絵, 笠井 俊輔, 赤松 真也子, 森川 暁, 田子森 順子, 江口 徹, 税所 芳史, 河合 俊英, 伊藤 裕, 中川 種昭
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Journal Title
日本歯周病学会会誌
Volume : 56(4)
Pages : 414-422
Related Report
Peer Reviewed / Open Access
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[Journal Article] xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma2013
Author(s)
Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, Onishi N, Masuko T, Yoshizawa K, Kawashiri S, Mukai M, Asoda S, Kawana H, Nakagawa T, Saya H, Nagano O
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Journal Title
Cancer Res
Volume : 73(6)
Pages : 1855-1866
DOI
Related Report
Peer Reviewed
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[Journal Article] Antibacterial activity of povidone-iodine against an artificial biofilm of Porphyromonas gingivalis and Fusobacterium nucleatum2012
Author(s)
Hosaka, Y., Saito, A., Maeda, R., Fukaya, C., Morikawa, S., Makino, A., Ishihara, K., Nakagawa, T
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Journal Title
Arch Oral Biol
Volume : 57
Pages : 364-368
DOI
Related Report
Peer Reviewed
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[Presentation] 当科における広範囲顎骨支持型装置・補綴治療の検討2013
Author(s)
奥原 優美, 臼田 慎, 莇生田 整治, 堀江 伸行, 岩崎 良太郎, 小高 利絵, 宮下 英高, 杉山 健太郎, 中川 種昭, 河奈 裕正
Organizer
第17回公益社団法人日本顎顔面インプラント学会総会・学術大会
Place of Presentation
日本歯科大学生命歯学部（東京都）
Related Report
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