| Project/Area Number |
24592968
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO Taichi 東京歯科大学, 歯学部, 講師 (80312015)
FURUYA Yoshitaka 東京歯科大学, 歯学部, 講師 (80385179)
HOMMA Shinya 東京歯科大学, 歯学部, 講師 (70408334)
SASAKI Hodaka 東京歯科大学, 歯学部, 講師 (50433959)
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| Co-Investigator(Renkei-kenkyūsha) |
MAKABE Yasushi (30707724)
MORI Gentaro (30733745)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | インプラント / インプラント周囲上皮 / インプラント周囲軟組織 / 遺伝子発現 / マイクロアレイ法 / マイクロアレイ / 口腔粘膜上皮 / 付着上皮 / 免疫組織化学染色法 / レーザーマイクロダイセクション法 |
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| Outline of Final Research Achievements |
Peri-implant soft tissue (PIST) was created by implant placement with epithelial penetration and known to have chronic inflammation. Therefore, we hypothesized PIST had risk factors for mucosal disease including oral carcinoma. The aim of this study was to determine specific genes in PIST to compare comprehensive gene expression between PIST and oral mucosal tissue (OMT) using microarray analysis and to clarify the relationship with oncognesis. The rattus PIST and OMT were used for samples and three specific gene; Ceacam1、Ifitm1、Muc4 were determined by microarray analysis Gene Ontology term. Cecam1 was reported to have defensive role by polymorohonuclear leukocytes activation. Moreover, high expression of Iftim1 and Muc4 was known to relate the oncogenensis. From these results, three specific gene expression in PIST have a possibility to influence the oral mucosal diseases.
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