| Project/Area Number |
24593005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Saitama Medical University |
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Principal Investigator |
YODA Tetsuya 埼玉医科大学, 医学部, 教授 (60242210)
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| Co-Investigator(Kenkyū-buntansha) |
AKITA Masumi 埼玉医科大学, 医学部, 教授 (60105905)
SAKAMOTO Yasushi 埼玉医科大学, 医学部, 教授 (80178582)
SATO Tsuyoshi 埼玉医科大学, 医学部, 准教授 (60406494)
SAKATA Yasuaki 埼玉医科大学, 医学部, 准教授 (50322425)
千田 大 独立行政法人国立国際医療研究センター, その他部局等, その他 (90312842)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 咀嚼筋腱・腱膜過形成症 / プロテオーム解析 / 元素分析 / ケイ素 / 石灰化 / 腱 / 電子顕微鏡 / 咀嚼筋腱腱膜過形成症 |
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| Outline of Final Research Achievements |
Masticatory muscle tendon-aponeurosis hyperplasia (MMTAH) is a new disease entity associated with limited mouth opening. In this study, we analyzed the microstructural characteristics of muscles and tendons in MMTAH by electron microscopy and energy dispersive X-ray analysis to determine the elemental composition. Histological analysis was performed to detect the calcification. Transmission electron microscopy and scanning electron microscopy were conducted to clarify the microstructural characteristics of muscles and tendons. Energy dispersive X-ray microanalysis was performed to identify the distribution of elements. Mineralized nodules were observed in tendon tissues of MMTAH as compared with facial deformity. Electron microscopy revealed that the muscle and tendon tissues in MMTAH showed degenerative changes and distinctive histological findings as compared with tissues in facial deformity. We found that Ca, P, and Si were detected only in MMTAH.
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