Identification of Sjogren's syndrome-associated antigens using heterozygous mutant mice systematically lacking of the PTEN
| Project/Area Number |
24593006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
近藤 誠二 昭和大学, 歯学部, 准教授 (10432634)
椋代 義樹 昭和大学, 歯学部, 助教 (50325099)
新谷 悟 昭和大学, 歯学部, 教授 (80294429)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | シェーグレン症候群 / PTEN |
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| Outline of Final Research Achievements |
The aim of this study was to evaluate identification of Sjogren's syndrome-associated antigens using heterozygous mutant mice systematically lacking of the phosphatase and tensin homolog (PTEN). Our results identified that the expression of PTEN of the salivary gland tissue diagnosed with Sjogren's syndrome was attenuated in every increasing Grade in tissue classification. Next, we evaluated the effect of salivary gland in heterozygous mutant mice systematically lacking of PTEN. It showed characteristic histology in Sjogren's syndrome. Accordingly, it is carried out mechanism analysis at the protein level for these results.
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Report
(4 results)
Research Products
(3 results)
