| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The aims of this study were to explore the feasibility of a novel combination therapy comprising hyperthermia(HT) and dendritic cell(DC) application for oral squamous cell carcinoma(OSCC) occult pulmonary metastasis model, and to optimize the conditions of this therapy. Our data suggest that the combination of 43℃preheated simple HT SCCVII tumors and additional 41℃heat mHT promotes DC maturation, resulting in suppression of tumor growth systemically and lifetime prolongation in occult pulmonary metastasis model mice. A three-step process of additional mHT after local HT and intratumoral immature DC(iDC) injection could be a more effective and novel method for the treatment of OSCC.
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