Optimization of hyperthermia and immunotherapy for squamous cell carcinoma.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593026
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Nagoya University
• Principal Investigator: YAMAMOTO NORIYUKI 名古屋大学, 医学(系)研究科(研究院), 助教 (60378156)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 温熱療法 / 免疫療法 / 樹状細胞 / 扁平上皮癌 / 口腔癌 / マイルド加温 / 磁性微粒子

Outline of Final Research Achievements

The aims of this study were to explore the feasibility of a novel combination therapy comprising hyperthermia(HT) and dendritic cell(DC) application for oral squamous cell carcinoma(OSCC) occult pulmonary metastasis model, and to optimize the conditions of this therapy. Our data suggest that the combination of 43℃preheated simple HT SCCVII tumors and additional 41℃heat mHT promotes DC maturation, resulting in suppression of tumor growth systemically and lifetime prolongation in occult pulmonary metastasis model mice. A three-step process of additional mHT after local HT and intratumoral immature DC(iDC) injection could be a more effective and novel method for the treatment of OSCC.

Free Research Field

医歯薬学