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Development of the screening method for oral cancer by metabolomics

Research Project

Project/Area Number 24593028
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionKobe University

Principal Investigator

KOMORI Takahide  神戸大学, 医学(系)研究科(研究院), 教授 (50251294)

Co-Investigator(Kenkyū-buntansha) SUZUKI Hiroaki  神戸大学, 医学部附属病院, 講師 (10397812)
TAKEUCHI Junichiro  神戸大学, 大学院医学研究科, 医学研究員 (30533757)
KIMOTO Akira  神戸大学, 医学部附属病院, 特定助教 (30597167)
Co-Investigator(Renkei-kenkyūsha) YOSHIDA Masaru  神戸大学, 大学院医学研究科, 准教授 (00419475)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords口腔がん / メタボローム解析 / スクリーニング / バイオマーカー / メタボローム / メタボロミクス
Outline of Final Research Achievements

Oral squamous cell carcinoma (OSCC) is the eleventh most common cancer in the world. The five-year survival rate of patients who are diagnosed with OSCC at an early stage is about 80-90%. On the other hand, at an advanced stage, the five-year survival rate is less than 30%. Therefore, it is important to detect OSCC at an early stage. In this study, we subjected OSCC patients’ serum samples to gas chromatography/mass spectrometry (GC/MS)-based metabolomic analysis.Their preoperative serum metabolite levels were compared with those of healthy volunteers. In addition, the pre- and postoperative serum metabolite levels of these patients were also compared. The metabolites that displayed significant differences were subjected to multiple logistic regression analysis, and it was found that models based on candidate biomarker pairs possessed greater accuracy than single biomarker candidates. GC/MS-based metabolomic analysis is a promising method for detecting early-stage OSCC.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] Oral squamous cell carcinoma with microscopic extracapsular spread in the cervical lymph nodes2014

    • Author(s)
      Shibuya Y, Ohtsuki Y, Hirai C, Hasegawa T, Akashi M, Shigeta T, Minamikawa T, Komori T
    • Journal Title

      Int J Oral Maxillofan Surg

      Volume: 43 Issue: 4 Pages: 387-392

    • DOI

      10.1016/j.ijom.2013.09.015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcutaneous Carbon Dioxide Induces Mitochondrial Apoptosis and Suppresses Metastasis of Oral Squamous Cell Carcinoma In Vivo.2014

    • Author(s)
      Takeda D, Hasegawa T, Ueha T, Imai Y, Sakakibara A, Minoda M, Kawamoto T, Minamikawa T, Shibuya Y, Akisue T, Sakai Y, Kurosaka M, Komori T.
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 7 Pages: e100530-e100530

    • DOI

      10.1371/journal.pone.0100530

    • NAID

      120005611288

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of postoperative chemotherapy and radiotherapy on patients with squamous cell carcinoma of the oral cavity and multiple regional lymph node metastases.2014

    • Author(s)
      Takahashi H, Yanamoto M, Yamada S, Umeda M, Shigeta T, Minamikawa T, Shibuya Y, Komori T, Shiraishi T, Asahina I, Yokoo S, Ri S.
    • Journal Title

      Int J Oral Maxillofac Surg

      Volume: 43 Issue: 6 Pages: 680-685

    • DOI

      10.1016/j.ijom.2013.11.013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Present status and prospects of loco-regional recurrence in patients with oral cancer2014

    • Author(s)
      梅田正博,柳本惣市,山田慎一,南川 勉,渋谷恭之,古森孝英
    • Journal Title

      Journal of Japanese Society of Oral Oncology

      Volume: 26 Issue: 4 Pages: 140-148

    • DOI

      10.5843/jsot.26.140

    • NAID

      130004838334

    • ISSN
      0915-5988, 1884-4995
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A multicenter retrospective study of the clinical outcomes of patients with delayed cervical lymph node metastasis in stage I-II squamous cell carcinoma of the oral cavity2014

    • Author(s)
      柳本惣市,上田倫弘,山下徹朗,太田嘉英,大鶴光信,栗太 浩,鎌田孝広,大倉正也,相川友直,古森孝英,重田崇至,桐田忠昭,山川延宏,梅田正博
    • Journal Title

      Journal of Japanese Society of Oral Oncology

      Volume: 26 Issue: 3 Pages: 103-112

    • DOI

      10.5843/jsot.26.103

    • NAID

      130004697717

    • ISSN
      0915-5988, 1884-4995
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel gas chromatography mass spectrometry-based serum screening method for oral squamous cell carcinoma2013

    • Author(s)
      Kimoto A, Nishiumi S, Kobayashi T, Terashima Y, Suzuki H, Takeuchi J, Azuma T, Komori T, Yoshida M.
    • Journal Title

      Head Neck Oncol.

      Volume: 5 Pages: 40-40

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 舌扁平上皮癌のリンパ節転移に関わる因子について2014

    • Author(s)
      松井太輝,重田崇至,筧 康正,高橋佑輔,南川 勉,李 進彰,渋谷恭之,梅田正博,古森孝英
    • Organizer
      第59回日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 局所的炭酸ガス投与による口腔癌新規治療法の開発2014

    • Author(s)
      武田大介,長谷川巧実,今井佑輔,榊原晶子,明石昌也,南川 勉,渋谷恭之,古森孝英
    • Organizer
      第59回日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 血清メタボローム解析から口腔がんの新規スクリーニング法の可能性を探る2013

    • Author(s)
      木本明、鈴木泰明、竹内純一郎、古森孝英
    • Organizer
      日本口腔外科学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] METABOLIC APPROACH TO ORAL SQUAMOUS CELL CARCINOMA BY GAS CHROMATOGRAPH MASS SPECTROMETRY2013

    • Author(s)
      Akira Kimoto, Shin Nishiumi, Takashi Kobayashi, Yoshihiko Terashima, Hiroaki Suzuki, Junichiro Takeuchi, Takeshi Azuma, Takahide Komori, Masaru Yoshida
    • Organizer
      International conference on oral and maxilofacial surgery
    • Place of Presentation
      Barcelona
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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