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Basic research for therapeutic indication of new molecular target drug for oral carcinoma

Research Project

Project/Area Number 24593041
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionTsurumi Junior College (2014)
Tsurumi University (2012-2013)

Principal Investigator

FUJIHARA Hisako  鶴見大学短期大学部, 歯科衛生科, 准教授 (80396746)

Co-Investigator(Kenkyū-buntansha) YAMADA Hiroyuki  鶴見大学, 歯学部, 講師 (90267542)
HORIUCHI Toshikatsu  鶴見大学, 歯学部, 非常勤講師 (90454165)
新井 剛  鶴見大学, 歯学部, 助教 (80454164)
Co-Investigator(Renkei-kenkyūsha) MASUTANI Mitsuko  国立がん研究センター研究所, ゲノム安定性研究分野, 分野長 (60238904)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords口腔癌 / 分子標的薬 / 口腔がん / 化学療法 / 放射線療法
Outline of Final Research Achievements

In this report, PARP inhibitor, new therapeutic molecular target drug currently indicated for breast cancer, was analyzed for possible indication for oral cancer therapy. Single administration of low dose of PARP inhibitor on cells derived from oral carcinoma did not show significant cell death, however, combination of cisplatin and PARP inhibitor administration showed significant cell death compared to single administration of cisplatin and PARP inhibitor respectively. Moreover, administration of cisplatin and PARP inhibitor combination on tumors derived from oral carcinoma cells injected to nude-mice also showed significant reduction of tumor growth compared to single administration of cisplatin and PARP inhibitor.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Solitary myofibroma of the mandible in an adult with magnetic resonance imaging and positron emission tomography findings: a case report.2014

    • Author(s)
      Tanaka Y, Yamada H, Saito T, Nakaoka K, Kumagai K, Fujihara H, Mishima K, Hamada Y.
    • Journal Title

      World Journal of Surgical Oncology

      Volume: 12 Issue: 1 Pages: 69-69

    • DOI

      10.1186/1477-7819-12-69

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 口腔がん由来細胞に対する化学療法におけるポリADP-リボース合成酵素 (PARP)阻害剤の効果2014

    • Author(s)
      安川 仁章、 藤原 久子、 岸 悠太、 山本 那々美、 山田 浩之、川口 浩司、 里村 一人、 益谷 美都子、 濱田 良樹
    • Organizer
      分子病理学研究会
    • Place of Presentation
      宮城蔵王ロイヤルホテル(宮城県刈田郡)
    • Year and Date
      2014-07-25 – 2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 口腔癌由来細胞に対する化学療法におけるポリADP-リボース合成酵素(PARP)阻害剤の効果2014

    • Author(s)
      安川 仁章, 藤原 久子, 岸 悠太, 山本 那々美, 山田浩之, 川口 浩司, 里村一人, 益谷美都子, 濱田 良樹
    • Organizer
      第33回分子病理研究会
    • Place of Presentation
      宮城蔵王ロイヤルホテル(宮城県)
    • Related Report
      2013 Research-status Report
  • [Book] 一般臨床医のための歯科小手術スキルアップ 第I章 歯科小手術のための基礎知識-歯科小手術にあたって注意すべき疾病および参考にすべきデータ-2014

    • Author(s)
      今村栄作、山田浩之編著
    • Publisher
      ヒョーロン社
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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