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Therapeutic strategy of intractable pain as targeting to antinociceptive dopaminergic neurons.

Research Project

Project/Area Number 24593046
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionTohoku University

Principal Investigator

OHTANI Norimasa  東北大学, 歯学研究科(研究院), 大学院非常勤講師 (60338879)

Co-Investigator(Kenkyū-buntansha) MASAKI Eiji  東北大学, 大学院歯学研究科, 教授 (40221577)
KIDO Kanta  東北大学, 大学病院, 助教 (40343032)
MIZUTA Kentaro  東北大学, 大学院歯学研究科, 準教授 (40455796)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords術後痛 / ドーパミン / BDNF / 下行性抑制性伝導路 / 鎮痛薬 / BDNF / 抗侵害神経
Outline of Final Research Achievements

To investigate whether the modification of dopamine antinociceptive neuron is involved in development of postoperative pain, we examined effects of IT administration of D2 agonist and antagonist on pain responses in a postoperative pain model. We also examined effects of a mast cell stabilizer, cromoglycade, and a microglia inhibitor, minocycline, on pain responses and BDNF production in the spinal cord, respectively. D2 agonist showed antinociceptive effects but D2 agonist did not change any pain responses. In addition, cromoglycade reduced pain behaviors whereas minocycline did not decrease both the pain threshold and the BDNF production. These results suggest that the modification of dopamine antinociceptive neuron could not be involved in the development of postoperative pain.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Efficacy of intrathecal esmolol on heat evoked responses in a postoperative pain model.2013

    • Author(s)
      Ono H. et. al
    • Journal Title

      Am J Ther

      Volume: In Press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mast cell stabilization promotes antinociceptive effects in a mouse model of postoperative pain.2013

    • Author(s)
      Yasuda M
    • Journal Title

      J Pain Res

      Volume: 6 Pages: 161-166

    • DOI

      10.2147/jpr.s41527

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Efficacy of Intrathecal Minocycline on Heat and Mechanical Stimuli Evoked Responses in a Postoperative Pain Model.2012

    • Author(s)
      Ono H.
    • Organizer
      The annual meeting of American society of Anesthesiologist.
    • Place of Presentation
      Washington, DC, USA
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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