Development of a treatment model for osteoporosis using an inner bone environment system
Project/Area Number |
24593054
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Okayama University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TSUJIGIWA Hidetsugu 岡山理科大学, 理学部, 教授 (70335628)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 骨 / 骨粗鬆症 / 間葉系幹細胞 / 骨再生 |
Outline of Final Research Achievements |
Our 3-year research study described that (1) CD34+, c-kit+, Sca1+ mesenchymal stem cells were easy to be differentiated to bone like cells. (2) Most suitable conditions for making beta-TCP as a mesenchymal stem cells scaffold were 1200C calcination temperature and through-holes structure with diameters of 300 micro-m. (3) Results from the study of our inner bone environments system showed that T cells especially gamma-delta T cells were affected by anti-osteoporosis drug and this mechanism may be explained by the Wnt10b cell signaling.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] マウス皮質骨由来細胞による骨再生2013
Author(s)
山近 英樹, 松原 正和, 喜多 憲一郎, 高畠 清文, 藤田 佑貴, 松村 達志, 平田 泰久, 飯田 征二
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Journal Title
日本口腔外科学会雑誌
Volume: 59(4)
Pages: 223-229
NAID
Related Report
Peer Reviewed
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[Presentation] The effects of risedronate and teriparatide to lymphocyte ratio2014
Author(s)
Eiki Yamachika, Kiyofumi Takabatake, Masakazu Matsubara, Yuuichi Matsui, Youhei Tataoka, Yuuki Fujita, Atsushi Ikeda, Nobuhisa Ishida, Hidetsugu Tsujigiwa, Hitoshi Nagatsuka, Seiji Iida
Organizer
American association of Oral and Maxillofacial Surgens 96th annual meeting
Place of Presentation
Honolulu HI
Year and Date
2014-09-09 – 2014-09-13
Related Report
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