| Project/Area Number |
24593063
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUTSUMI Sadami 金沢工業大学, 先端電子技術応用研究所, 客員教授 (00028739)
HONDA Kazuya 日本大学, 歯学部, 教授 (30199567)
NAMAKI Shunsuke 日本大学, 歯学部, 助教 (70386077)
OOKI Hiderou 日本大学, 歯学部, 教授 (80147628)
UEHARA Hiroyuki 日本大学, 歯学部, 非常勤医員 (90409102)
姜 有峯 日本大学, 歯学部, 研究員 (40437273)
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| Research Collaborator |
MASHIMO Takayuki
IWATA Jun
URYU Takeshi
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 骨再生 / 骨造成 / 人工骨 / 画像評価 |
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| Outline of Final Research Achievements |
The observation of the bone regenerative process from periosteum suggest that the periosteum has osteogenic capacity and the peak of bone regeneration from the periosteum occurs around 4 to 6 weeks. The evaluation of the usefulness of regenerative bone from periosteum as a new graft material for the repair of bone defects indicate that the regenerative bone from periosteum is a useful reconstructive material. The results of tetrapod-shaped granular artificial bone(TB) implantation suggest that TB presented good shape stability and mechanical strength. TB might be useful for bone augmentation of flat bone area as compared with other currently used artificial graft materials and autogenous bone. The results of bone defect repair study showed higher volumes of the newly formed bones in the TB and collagen implantation group than in the TB group or control group. The combinatorial use of TB and collagen would be an effective strategy for the treatment of bone defect.
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