Role of bone metabolism caused by mechanical stress in SHIP KO mice

• Project/Area Number: 24593099
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Nagasaki University
• Principal Investigator: YOSHIMATSU Masako 長崎大学, 病院(歯学系), 助教 (20420630)
• Co-Investigator(Kenkyū-buntansha): KITAURA Hideki 東北大学, 歯学研究科(研究院), 准教授 (60295087) ; HOTOKEZAKA Hitoshi 長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (90199513) ; FUJIMURA Yuji 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (70448504)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: SHIP / TNF-α / 破骨細胞 / 矯正

Outline of Final Research Achievements

SHIP (SH2-containing inositol-5'-phosphatase) plays an important role for signal transduction of B cell receptor in immunoreaction. In bone metabolism, closely associated with immunology, SHIP also has been researched in recent years. We showed that SHIP might negatively regulate TNF-α mediated osteoclastogenesis in vitro. We also investigated the effect of SHIP caused by methanical stress using an orthodontic tooth movement model in vivo. The amount of tooth movement in SHIP knockout mice wasn’t significantly increased compared with control mice.

Research Products

• [Journal Article] IL-12 Inhibits Lipopolysaccharide Stimulated Osteoclastogenesis in Mice (2015)
  • Author(s): Masako Yoshimatsu, Hideki Kitaura, Yuji Fujimura, Haruka Kohara, Yukiko Morita, and Noriaki Yoshida
  • Journal Title: Journal of Immunology Research Volume: 2015 Pages: 1-8
  • DOI: 10.1155/2015/214878
  • NAID: 120006987060
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of cytokines on osteoclast formation and bone resorption during mechanical force loading of the periodontal membrane (2014)
  • Author(s): Kitaura H, Kimura K, Ishida M, Sugisawa H, Kohara H, Yoshimatsu M, Takano-Yamamoto T
  • Journal Title: Scientific World Journal Volume: 19 Pages: 1-7
  • DOI: 10.1155/2014/617032
  • Peer Reviewed / Open Access
• [Journal Article] Immunological reaction in TNF- α-mediated osteoclast formation and bone resorption in vitro and in vivo (2013)
  • Author(s): Kitaura H, Kimura K, Ishida M, Kohara H, Yoshimatsu M, Takano-Yamamoto T
  • Journal Title: Clin Dev Immunol Volume: 2013 Pages: 1-8
  • DOI: 10.1155/2013/181849
  • Peer Reviewed
• [Journal Article] Inhibitory effect of IFN-γ on experimental toothmovement in mice. (2012)
  • Author(s): Kohara, H., Kitaura, H., Yoshimatsu, M., Fujimura, Y., Morita, Y., Eguchi, T., Yoshida, N.
  • Journal Title: J. Interferon Cytokine. Res. Volume: 32 Issue: 9 Pages: 426-431
  • DOI: 10.1089/jir.2011.0124
  • Peer Reviewed
• [Presentation] LPSによる破骨細胞形成に対するIL-12の抑制機序 (2013)
  • Author(s): 吉松 昌子，北浦 英樹，藤村 裕治，小原 悠，森田 幸子，吉田 教明
  • Organizer: 日本矯正歯科学会
  • Place of Presentation: キッセイ文化ホール（松本市）
• [Presentation] 矯正学的歯の移動時におこる歯根吸収に対するIFN-γの作用について (2013)
  • Author(s): 小原 悠，北浦 英樹，吉松 昌子，藤村 裕治，森田 幸子，吉田 教明
  • Organizer: 日本矯正歯科学会
  • Place of Presentation: キッセイ文化ホール（松本市）
• [Presentation] Effects of IL-12 on mechanical loadong induced bone resorption (2012)
  • Author(s): Yoshimatsu M, Kitaura H, Fujimura Y, Kohara H, Morita Y, Eguchi T, Yoshida N
  • Organizer: Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Convention Center in Minneapolis (Minneapolis)
• [Presentation] IFN-γ inhibits mechanical stress-induced osteoclastogenesis and bone resorption (2012)
  • Author(s): Kohara H, Kitaura H, Yoshimatsu M, Fujimura Y, Morita Y, Eguchi T, Yoshida N
  • Organizer: Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Convention Center in Minneapolis (Minneapolis)
• [Presentation] IL-12がメカニカルストレスによる骨吸収に及ぼす影響 (2012)
  • Author(s): 吉松昌子，北浦英樹，小原 悠，森田幸子，藤村裕治
  • Organizer: 日本骨代謝学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都）
• [Presentation] メカニカルストレスに対するIFN-γの発現およびその影響 (2012)
  • Author(s): 小原 悠，北浦英樹，吉松昌子，森田幸子，藤村裕治
  • Organizer: 日本骨代謝学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都）
• [Presentation] IL-12がLPS誘導破骨細胞形成に及ぼす影響 (2012)
  • Author(s): 吉松昌子，北浦英樹，藤村裕治，小原 悠，森田幸子，吉田教明
  • Organizer: 日本矯正歯科学会大会
  • Place of Presentation: アイスアリーナ（盛岡市）
• [Presentation] メカニカルストレスに対する歯根周囲組織におけるINF-γの影響 (2012)
  • Author(s): 小原 悠，北浦英樹，吉松昌子，藤村裕治，森田幸子，吉田教明
  • Organizer: 日本矯正歯科学会大会
  • Place of Presentation: アイスアリーナ（盛岡市）