Associations between PPARgamma gene polymorphism and periodontitis, obesity and osteoporosis in postmenopausal women

• Project/Area Number: 24593121
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Niigata University
• Principal Investigator: SUGITA Noriko 新潟大学, 医歯学系, 助教 (30313547)
• Co-Investigator(Renkei-kenkyūsha): NAKAMURA Kazutoshi 新潟大学, 医歯学系, 教授 (70207869)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 歯学 / 歯周炎 / 骨密度 / 肥満 / ゲノム / 閉経後女性 / PPARガンマ / 遺伝子型 / 骨粗鬆症

Outline of Final Research Achievements

Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear hormone receptor and regulates inflammation, lipid and bone metabolism. Previous studies reported associations between polymorphisms in PPARgamma gene and inflammation, obesity and osteoporosis. Postmenopausal women have higher risks for these diseases. Therefore, to elucidate whether PPARgamma Pro12Ala polymorphism was a common risk factor for the diseases, we assessed possible associations between the genotypes and parameters of obesity, osteoporosis and periodontitis in 359 postmenopausal Japanese women living in Niigata City. As a result, the Ala allele carriage was suggested to enhance associations between periodontitis and obesity or osteoporosis. The finding might contribute to risk diagnosis and suggest possible effects of PPARgamma regulation in therapies of these diseases.

Research Products

• [Journal Article] The interaction between beta-3 adrenergic receptor and PPAR gamma gene polymorphism to periodontal disease in community-dwelling elderly Japanese. (2015)
  • Author(s): Yoshihara K, Sugita N, Iwasaki M, Wang Y, Miyazaki H, Yoshie H, Nakamura K.
  • Journal Title: Journal of Periodnotlogy Volume: Ahead of print
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women (2015)
  • Author(s): Hanai Y, Sugita N, Wang Y, Yoshihara A, Iwasaki M, Miyazaki H, Nakamura K, Yoshie H
  • Journal Title: Arch Oral Bioｌ Volume: 60 Issue: 4 Pages: 533-9
  • DOI: 10.1016/j.archoralbio.2014.12.005
  • Peer Reviewed
• [Journal Article] PPARγ gene polymorphism, C-reactive protein level, BMI and periodontitis in postmenopausal Japanese women (2015)
  • Author(s): Wang Y, Sugita N, Yoshihara A, Iwasaki M, Miyazaki H, Nakamura K, Yoshie H
  • Journal Title: Gerodontology Volume: 印刷中 Issue: 1 Pages: 44-51
  • DOI: 10.1111/ger.12110
  • Peer Reviewed
• [Journal Article] The interaction between beta-3 adrenergic receptor polymorphism and obesity to periodontal disease in community-dwelling elderly Japanese (2014)
  • Author(s): Yoshihara A, Sugita N, Iwasaki M, Miyazaki H, Nakamura K
  • Journal Title: J Clin Periodontol Volume: 41 Issue: 5 Pages: 460-6
  • DOI: 10.1111/jcpe.12235
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Peroxisome proliferator-activated receptor (PPAR) γ polymorphism, vitamin D, bone mineral density and periodontitis in postmenopausal women. (2013)
  • Author(s): Wang Y, Sugita N, Yoshihara A, Iwasaki M, Miyazaki H, Nakamura K, Yoshie H
  • Journal Title: Oral Dis Volume: 19(5) Issue: 5 Pages: 501-506
  • DOI: 10.1111/odi.12032
  • Peer Reviewed
• [Presentation] Associations between numbers of teeth and serum cytokine levels in Japanese adults: A cross-sectional study from PROST. (2014)
  • Author(s): Sugita N, Hanai Y, Kobayashi T, Yoshihara A, Yoshie H.
  • Organizer: 第62回国際歯科研究学会日本部会学術大会
  • Place of Presentation: 大阪、KKRホテル大阪
  • Year and Date: 2014-12-05
• [Presentation] Relationships between IL-6 gene polymorphism, bone mineral density and periodontitis. (2014)
  • Author(s): Hanai H, Sugita N, Yoshihara A, Iwasaki M, Miyazaki H, Nakamura K, Yoshie H.
  • Organizer: 国際歯科研究学会
  • Place of Presentation: 南アフリカ共和国、ケープタウン国際会議場
  • Year and Date: 2014-06-25 – 2014-06-28
• [Presentation] UCP3 gene polymorphism associated with serum vitamin D levels and periodontitis in postmenopausal Japanese women. (2014)
  • Author(s): Sugita N, Yoshihara A, Wang Y, Hanai H, Iwasaki M, Miyazaki H, Nakamura K, Yoshie H.
  • Organizer: Human Genome Meeting 2014
  • Place of Presentation: スイス連邦、ジュネーブ国際会議場
  • Year and Date: 2014-04-27 – 2014-04-30
• [Presentation] IL-6 polymorphism and relationships between periodontitis and adiposity in postmenopausal Japanese woman.
  • Author(s): Sugita N, Wang Y, Yohihara A, Iwasaki M, Miyazaki H, Nakamura K, Yoshie H.
  • Organizer: EuroPerio7
  • Place of Presentation: Viena, Austria
• [Presentation] Peroxisome proliferator-activated receptor gamma polymorphism in postmenopausal Japanese women with periodontitis and osteoporosis.
  • Author(s): Wang Y, Sugita N, Yohihara A, Iwasaki M, Miyazaki H, Nakamura K, Yoshie H.
  • Organizer: EuroPerio7
  • Place of Presentation: Viena, Austria
• [Presentation] Effects of genetic polymorphisms between periodontal diseases and systemic diseases in women.
  • Author(s): Wang Y, Sugita N, Yoshie H.
  • Organizer: The 14th Chinese Stomatological Association Annual Meeting
  • Place of Presentation: Xian, China
• [Presentation] Effects of genetic polymorphisms on maternal periodontal disease and pregnancy outcomes.
  • Author(s): Sugita N, Wang Y, Yoshie H.
  • Organizer: Harbin Periodontology Meeting
  • Place of Presentation: Harbin, China
  • Invited
• [Presentation] CRP levels in postmenopausal women with PPAR polymorphism and periodontitis.
  • Author(s): Wang Y, Sugita N, Yohihara A, Iwasaki M, Miyazaki H, Nakamura K, Yoshie H.
  • Organizer: The 60th Annual Meeting of Japanese Association for Dental Research
  • Place of Presentation: 新潟市
• [Presentation] PPAR gamma, albumin, obesity and periodontitis in postmenopausal Japanese women.
  • Author(s): Wang Y, Sugita N, Yohihara A, Iwasaki M, Miyazaki H, Nakamura K, Yoshie H.
  • Organizer: 第55回秋季日本歯周病学会総会学術大会
  • Place of Presentation: つくば市