Usefulness of the complex consisting of three regenerative factors, which can be processed and shaped in vitro for regeneration of severely destructed periodontal tissues
Project/Area Number |
24593122
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Periodontal dentistry
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Research Institution | Hiroshima University |
Principal Investigator |
SHIBA Hideki 広島大学, 医歯薬保健学研究院(歯), 教授 (60260668)
|
Co-Investigator(Kenkyū-buntansha) |
FUJITA Tsuyoshi 広島大学, 病院, 講師 (80379883)
TAKEDA Katsuhiro 広島大学, 大学院医歯薬保健学研究院, 助教 (10452591)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 歯周療法学 / 歯周組織再生 / 幹細胞 / 細胞外基質 / LL37 / 再生3要素 / 歯周外科学 / 再生3要素 |
Outline of Final Research Achievements |
We developed the ball-shaped mesenchymal stem cell complex (B-MSC) which contains bone marrow-derived MSC, self-produced extracellular matrices and no artificial scaffold, and which can be processed in vitro. Furthermore, the osteogenic-differentiated B-MSC and the synthesized LL37 which increases the production of vascular endothelial growth factor enhanced bone regeneration in the rat calvarial defect model. Therefore, the transplantation of B-MSC and LL37 may represent a novel tissue engineering therapy for regeneration of periodontal tissues (bone).
|
Report
(4 results)
Research Products
(6 results)
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[Journal Article] Clumps of a mesenchymal stromal cell/extracellular matrix complex can be a novel tissue engineering therapy for bone regeneration.2015
Author(s)
Kittaka M, Kajiya M, Shiba H, Takewaki M, Takeshita K, Khung R, Fujita T, Iwata T, Nguyen TQ, Ouhara K, Takeda K, Fujita T, Kurihara H.
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Journal Title
Cytotherapy.
Volume: 2
Issue: 7
Pages: 48-61
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The antimicrobial peptide LL37 promotes bone regeneration in a rat calvarial bone defect2013
Author(s)
Kittaka M., Shiba H., Kajiya M., Fuita T., Iwata T., Rathvisa K., Ouhara K., Takeda K., Fujita T., Komatsuzawa H., Kurihara, H.
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Journal Title
Peptides
Volume: 46
Pages: 136-42
DOI
Related Report
Peer Reviewed
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